Relationships between anthropometric adiposity indexes and bone mineral density in a cross-sectional Chinese study |
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| Authors: | Guijuan Deng Lu Yin Kai Li Bo Hu Xiaoru Cheng Ling Wang Yong Zhang Li Xu Shaoqi Xu Lei Zhu Jiman Shao Xiaoguang Hao Jun Zhou Jinhua Tang Wei Li Yu Jiang Xiaoguang Cheng |
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| Institution: | 1. Medical Research and Biometrics Center, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Fuwai Hospital, Beijing, China;2. School of Public Health, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China;3. Department of Radiology, Beijing Jishuitan Hospital, Beijing, China;4. Department of Radiology, Nanjing University of Chinese Medicine Affiliated Wujin Hospital of Traditional Chinese Medicine, Changzhou 213161, China;5. Department of Radiology, The People''s Hospital of Dayi County, Chengdu, China;6. Department of Radiology, The Affiliated Hospital of Jiangxi University of Traditional Chinese Medicine, Nanchang, China;7. Department of Radiology, Taiyuan Central Hospital, Taiyuan, China;8. Department of Radiology, The Fourth People''s Hospital of Shenyang, Shenyang, China;9. Nanjing Xiaohang Hospital, Nanjing, China;1. The University of Texas Dell Medical School, Ascension Texas Spine and Scoliosis, Austin, TX, USA;3. State University of New York Upstate Medical University, 750 East Adams St, Syracuse, NY 13210-2375, USA;4. Tufts Medical Center, 800 Washington St, Boston, MA 02111, USA;5. Cleveland Clinic, 9500 Euclid Ave, Cleveland, OH 44195, USA;6. Case Western Reserve University, 10900 Euclid Ave, Cleveland, OH 44106, USA;1. Department of Orthopedics, Taipei Medical University Hospital, Taipei 11031, Taiwan;2. Department of Orthopaedics, School of Medicine, College of Medicine, Taipei Medical University, Taipei 11031, Taiwan;3. Department of Medical Education, Taipei Veterans General Hospital, Taipei 11217, Taiwan;4. Graduate Institute of Clinical Medical Sciences, College of Medicine, Chang Gung University, Taoyuan 33302, Taiwan;5. Research Center of Biostatistics, Taipei Medical University, Taipei 11031, Taiwan;6. Department of Orthopaedic Surgery, National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University, Tainan 70101, Taiwan;7. Skeleton Materials and Bio-compatibility Core Lab, Research Center of Clinical Medicine, National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University, Tainan 70101, Taiwan;8. Medical Device Innovation Center (MDIC), National Cheng Kung University, Tainan 70101, Taiwan;9. Department of Orthopaedics, Ditmanson Medical Foundation Chia-Yi Christian Hospital, Chiayi City 60002, Taiwan;1. Department of Orthopaedic Surgery, Hyogo College of Medicine, 1-1 Mukogawa-cho, Nishinomiya, Hyogo 663-8501, Japan;2. Department of Anatomy and Neuroscience, Hyogo College of Medicine, 1-1 Mukogawa-cho, Nishinomiya, Hyogo 663-8501, Japan;1. Second Department of Spine Surgery, Changzheng Hospital, Second Military Medical University, 415 Fengyang Rd, Shanghai, China, 200001;2. Department of Spine Surgery, Changhai Hospital, Second Military Medical University, 168 Changhai Rd, Shanghai, China, 200433;3. Department of Spine Surgery, Shanghai First People''s Hospital, Shanghai Jiao Tong University, 85 Wujin Rd, Shanghai, China, 200080;4. Department of Orthopedics, Linzhou Hospital of Traditional Chinese Medicine, 244 Taihang Rd, Linzhou, China, 456550;5. Department of Orthopedics, Fifth Hospital of Southern Medical University, Southern Medical University, 566 Congcheng Ave, Guangzhou, China, 510900;6. Department of Spine Surgery, Shenzhen Hospital of Beijing University, 1120 Lianhua Rd, Shenzhen, China, 518036;7. Department of Spine Surgery, General Hospital of Nanjing Military Command, 305 East Zhongshan Rd, Nanjing, China, 210000 |
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| Abstract: | Background ContextPrevious studies have reported conflicting results for the relationships between anthropometric adiposity indexes and bone mineral density, based on dual-energy X-ray absorptiometry (DXA). However, few studies were published based on quantitative computed tomography (QCT), especially for Chinese population.PurposeTo evaluate the associations of spine bone mineral density (BMD) with body mass index (BMI), waist circumstance (WC), waist-to-hip ratio (WHR), waist-to-height ratio (WHtR) and a body shape index (ABSI) using QCT.Study Design/SettingA Cross-sectional study.Patient SampleAround 3,457 participants in multiple communities across 7 administrative regions of China.Outcome MeasuresSpine BMD was measured using QCT, and the classification of osteoporosis was defined as follows: 1) osteoporosis if BMD <80mg/cm3, 2) osteopenia if BMD 80–119 mg/cm3, and 3) normal bone mass if BMD≥120 mg/cm3.MethodsThis study was conducted using convenient sampling between 2013 and 2017. Multivariable linear regression model and logistic regression models were used for the associations of continuous and categorical BMD, respectively.ResultsAround 3,405 participants were included in the final analyses, including 1,272 males and 2,133 females, with spine BMD of 111.00±35.47 mg/cm3 and 99.38±40.60 mg/cm3, respectively. Spine BMD decreased significantly with the increase of ABSI in females (adjusted β, ?5.74; 95% confidence interval CI], ?8.50 to ?2.98), and this trend also was kept in females aged at less than 60 years (adjusted β, ?14.54; 95% CI, ?20.40 to ?8.68), and females with age ≥60 years (adjusted β, ?7.59; 95% CI, ?10.91 to ?4.28). However, this inverse association was observed only in males with age ≥ 60 years (adjusted β, ?5.19; 95% CI, ?10.08 to ?0.29). Except ABSI, negative associations of Spine BMD with WC (adjusted β, ?0.46; 95% CI, ?0.77 to ?0.15), WHR (adjusted β, ?6.25; 95% CI, ?10.63 to ?1.86), WHtR (adjusted β, ?6.80; 95% CI, ?11.63 to ?1.97) were shown in females aged at <60 years, and positive association with BMI in males with age ≥60 years (adjusted β, 0.92; 95% CI, 0.29–1.55).ConclusionsABSI had more remarkable association with spine BMD, compared with the other four indexes. |
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