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HDAC and MAPK/ERK Inhibitors Cooperate To Reduce Viability and Stemness in Medulloblastoma |
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| Authors: | da Cunha Jaeger Mariane Ghisleni Eduarda Chiesa Cardoso Paula Schoproni Siniglaglia Marialva Falcon Tiago Brunetto André T. Brunetto Algemir L. de Farias Caroline Brunetto Taylor Michael D. Nör Carolina Ramaswamy Vijay Roesler Rafael |
| Affiliation: | 1.Cancer and Neurobiology Laboratory, Experimental Research Center, Clinical Hospital (CPE-HCPA), Federal University of Rio Grande do Sul, Porto Alegre, RS, Brazil ;2.Children’s Cancer Institute, Porto Alegre, RS, Brazil ;3.Bioinformatics Core, Experimental Research Center, Clinical Hospital (CPE-HCPA), Federal University of Rio Grande do Sul, Porto Alegre, RS, Brazil ;4.The Arthur and Sonia Labatt Brain Tumour Research Centre, The Hospital for Sick Children, Toronto, ON, Canada ;5.Developmental and Stem Cell Biology Program, The Hospital for Sick Children, Toronto, ON, Canada ;6.Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, ON, Canada ;7.Division of Neurosurgery, The Hospital for Sick Children, Toronto, ON, Canada ;8.Division of Haematology/Oncology, The Hospital for Sick Children, Toronto, ON, Canada ;9.Department of Pharmacology, Institute for Basic Health Sciences, Federal University of Rio Grande do Sul, Rua Sarmento Leite, 500 (ICBS, Campus Centro/UFRGS), Porto Alegre, RS, 90050-170, Brazil ; |
| Abstract: | Journal of Molecular Neuroscience - Medulloblastoma (MB), which originates from embryonic neural stem cells (NSCs) or neural precursors in the developing cerebellum, is the most common malignant... |
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