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Inter- and Intra-individual Variation,and Limited Prognostic Utility,of Serum Alkaline Phosphatase in a Trial of Patients With Primary Sclerosing Cholangitis
Authors:Palak J. Trivedi  Andrew J. Muir  Cynthia Levy  Christopher L. Bowlus  Michael P. Manns  Xiaomin Lu  Gerald Crans  Chuhan Chung  G. Mani Subramanian  Robert P. Myers  Zachary Goodman  Naga Chalasani  John M. Vierling  Indra Neil Guha  Gideon M. Hirschfield
Affiliation:1. National Institute for Health Research (NIHR) Birmingham Biomedical Research Centre, Birmingham, United Kingdom;3. University Hospitals Birmingham, Birmingham, United Kingdom;4. Institute of Immunology and Immunotherapy, University of Birmingham, Birmingham, United Kingdom;6. Institute of Applied Health Research, University of Birmingham, Birmingham, United Kingdom;5. Duke Clinical Research Institute, Durham, North Carolina;7. University of California Davis, Davis, California;12. Department of Gastroenterology, Hepatology and Endocrinology, Hannover Medical School, Hannover, Germany;8. Gilead Sciences, Inc, Foster City, California;10. Inova Fairfax Hospital, Falls Church, Virginia;9. Indiana University School of Medicine, Indianapolis, Indiana;71. NIHR Nottingham Biomedical Research Centre, Nottingham University Hospitals NHS Trust and the University of Nottingham, Nottingham, United Kingdom;123. Toronto Centre for Liver Disease, University Health Network, University of Toronto, Toronto, ON, Canada
Abstract:
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  • Keywords:Cholestasis  Biomarker  Immune-Mediated Liver Disease  Prognostic Factor  ALP"  },{"  #name"  :"  keyword"  ,"  $"  :{"  id"  :"  kwrd0035"  },"  $$"  :[{"  #name"  :"  text"  ,"  _"  :"  alkaline phosphatase  CV"  },{"  #name"  :"  keyword"  ,"  $"  :{"  id"  :"  kwrd0045"  },"  $$"  :[{"  #name"  :"  text"  ,"  _"  :"  coefficient of variation  ELF"  },{"  #name"  :"  keyword"  ,"  $"  :{"  id"  :"  kwrd0055"  },"  $$"  :[{"  #name"  :"  text"  ,"  _"  :"  enhanced liver fibrosis  HR"  },{"  #name"  :"  keyword"  ,"  $"  :{"  id"  :"  kwrd0065"  },"  $$"  :[{"  #name"  :"  text"  ,"  _"  :"  hazard ratio  IQR"  },{"  #name"  :"  keyword"  ,"  $"  :{"  id"  :"  kwrd0075"  },"  $$"  :[{"  #name"  :"  text"  ,"  _"  :"  interquartile range  PSC"  },{"  #name"  :"  keyword"  ,"  $"  :{"  id"  :"  kwrd0085"  },"  $$"  :[{"  #name"  :"  text"  ,"  _"  :"  primary sclerosing cholangitis  SD"  },{"  #name"  :"  keyword"  ,"  $"  :{"  id"  :"  kwrd0095"  },"  $$"  :[{"  #name"  :"  text"  ,"  _"  :"  standard deviation  UDCA"  },{"  #name"  :"  keyword"  ,"  $"  :{"  id"  :"  kwrd0105"  },"  $$"  :[{"  #name"  :"  text"  ,"  _"  :"  ursodeoxycholic acid  ULN"  },{"  #name"  :"  keyword"  ,"  $"  :{"  id"  :"  kwrd0115"  },"  $$"  :[{"  #name"  :"  text"  ,"  _"  :"  upper limit of normal
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