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Interactions between cancer cells and immune cells drive transitions to mesenchymal-like states in glioblastoma
Authors:Toshiro Hara  Rony Chanoch-Myers  Nathan D. Mathewson  Chad Myskiw  Lyla Atta  Lillian Bussema  Stephen W. Eichhorn  Alissa C. Greenwald  Gabriela S. Kinker  Christopher Rodman  L. Nicolas Gonzalez Castro  Hiroaki Wakimoto  Orit Rozenblatt-Rosen  Xiaowei Zhuang  Jean Fan  Tony Hunter  Inder M. Verma  Kai W. Wucherpfennig  Itay Tirosh
Affiliation:1. Department of Pathology and Center for Cancer Research, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA;2. Klarman Cell Observatory, Broad Institute of Harvard and MIT, Cambridge, MA 02142, USA;3. Broad Institute of Harvard and MIT, Cambridge, MA 02142, USA;4. Laboratory of Genetics, Salk Institute for Biological Studies, La Jolla, CA 92037, USA;5. Department of Molecular Cell Biology, Weizmann Institute of Science, Rehovot 761001, Israel;6. Department of Cancer Immunology and Virology, Department of Microbiology and Immunobiology, Department of Neurology, Dana-Farber Cancer Institute and Harvard Medical School, Boston, MA 02215, USA;7. Department of Biomedical Engineering, Johns Hopkins University, Baltimore, MD 21218, USA;8. Howard Hughes Medical Institute, Harvard University, Cambridge, MA 02138, USA;9. Department of Chemistry and Chemical Biology, Department of Physics, Harvard University, Cambridge, MA 02138, USA;10. Department of Physiology, Institute of Bioscience, University of Sao Paulo, Sao Paulo, Brazil;11. Department of Neurology and Center for Neuro-Oncology, Brigham and Women’s - Dana-Farber Cancer Center and Harvard Medical School, Boston, MA 02115, USA;12. Department of Neurosurgery, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA;13. Howard Hughes Medical Institute, Koch Institute for Integrative Cancer Research, Department of Biology, MIT, Cambridge, MA 02139, USA
Abstract:
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  • Keywords:glioblastoma  GBM  scRNA-seq  mesenchymal  tumor microenvironment  macrophage  OSM
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