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Peripheral blood stem cell grafts in allogeneic hematopoietic cell transplantation: It is not all about the CD34+ cell dose
Authors:Ran Reshef
Affiliation:1. Department of Health Metric Sciences, Institute for Health Metrics and Evaluation, University of Washington, Seattle, WA, United States;2. Division of Pathology & Laboratory Medicine, Children’s National Medical Center, Washington, DC, United States;3. Departments of Pathology & Pediatrics, George Washington University Medical School, Washington DC, United States;4. Department of Medicine, Division of Hematology, University of Washington, Seattle, WA, United States;1. Unidade de Hemoterapia e Hematologia Samaritano, São Paulo, Brazil;2. Instituto de Tratamento do Câncer Infantil, University of São Paulo School of Medicine, São Paulo, Brazil;3. Fundação Pró-Sangue Hemocentro de São Paulo, São Paulo, Brazil;1. Apheresis & Cellular Therapy Unit, Department of Hemotherapy and Hemostasis, ICMHO, IDIBAPS, Hospital Clínic, University of Barcelona, Barcelona Catalonia, Spain;2. Department of Hematology, ICMHO, IDIBAPS, Hospital Clínic, University of Barcelona, Barcelona Catalonia, Spain;3. Hematopathology, Department of Pathology, Centre de Diagnòstic Biomèdic (CDB), IDIBAPS, Hospital Clínic, University of Barcelona, Barcelona Catalonia, Spain;4. Barcelona Endothelium Team, Barcelona, Spain;1. INSERM_U1059, Faculty of Medicine of Saint-Etienne, University of Lyon-Saint-Etienne, Saint-Etienne, France;2. Institut National de la Transfusion Sanguine, Paris, France;3. Sorbonne Université, Inserm IPLESP, hôpital St Antoine, AP-HP, Paris, France;4. Etablissement Français du Sang, La Plaine, St Denis, France;5. UMR RIGHT 1098, Inserm, Etablissement Français du Sang, Université de Franche-Comté, Besançon, France;1. Blood Bank, Department of Clinical Pathology, University Hospital “Dr. José E. González”, Universidad Autónoma de Nuevo León;2. Liver Unit, Department of Internal Medicine, University Hospital “Dr. José E. González”, Universidad Autónoma de Nuevo León
Abstract:
Allogeneic Hematopoietic Cell Transplantation is a curative approach in various malignant and non-malignant disorders. The majority of adult transplants in the current era are performed using mobilized stem cells, harvested from the peripheral blood by leukapheresis. Peripheral blood stem cell (PBSC) collections are designed to target a dose of stem cells that will result in safe engraftment and hematopoietic recovery; however, 99 % of the cells contained in a PBSC graft are not stem cells and a growing number of studies attempt to characterize the associations between graft composition and transplant outcomes. A better understanding of the impact of the quantity and quality of various cell types in PBSC grafts may lead to development of novel collection strategies or improved donor selection algorithms. Here we review relevant findings from recent studies in this area.
Keywords:Allogeneic hematopoietic cell transplantation  Peripheral blood stem cells
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