| 单核细胞趋化蛋白-1与中枢神经系统疾病 |
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| 引用本文： | 许莉,张祥建.单核细胞趋化蛋白-1与中枢神经系统疾病[J].国际脑血管病杂志,2005,13(8):626-629. |
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| 作者姓名： | 许莉 张祥建 |
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| 作者单位： | 050000,石家庄,河北医科大学第二医院神经内科 |
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| 基金项目： | 河北省重大课题(0527610D27) |
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| 摘 要： | 单核细胞趋化蛋白1(MCP1)是趋化因子CC类亚家族成员之一,可趋化和激活单核细胞、T淋巴细胞等免疫细胞,促进多种细胞因子和炎症介质分泌,参与脑缺血再灌注损伤、创伤性脑损伤、实验性自身免疫性脑脊髓炎、AIDS脑病和中枢神经系统肿瘤等疾病的病理生理学过程。深入研究MCP1在中枢神经系统疾病中的作用机制,有可能为这些疾病的治疗找到一条新的途径。
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| 关 键 词： | 单核细胞趋化蛋白-1 中枢神经系统疾病 趋化因子 |
| 修稿时间： | 2005年1月11日 |
Monocyte Chemoattractant Protein-1 and the Central Nervous System Diseases |
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| Li Xu,Xiang-Jian Zhang.Monocyte Chemoattractant Protein-1 and the Central Nervous System Diseases[J].International Journal of Cerebrovascular Diseases,2005,13(8):626-629. |
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| Authors: | Li Xu Xiang-Jian Zhang |
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| Abstract: | Monocyte chemoattractant protein-1 (MCP-1) is one of CC chemokines. It can attract and activate immune cells, such as monocytes and T lymphocytes, promote the secretion of cytokines and inflammation mediators, participate in some pathology processes of the diseases, including cerebral ischemia/reperfusion injury, traumatic brain injury, exeperimental autoimmune encephalomyelitis, AIDS encephalopathy and central nervous system (CNS) tumors. To furthur study the mechanism of MCP-1 in CNS diseases may find a new way for the treatment of these diseases. |
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| Keywords: | monocyte chemoattractant protein-1 central nervous system diseases chemokines |
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