瘢痕疙瘩中国家系的发病特点研究

目的:研究瘢痕疙瘩中国家系的发病特点。方法:通过收集六个无亲缘关系的瘢痕疙瘩中国家系的临床资料,寻找它们发病的共同特点。结果:瘢痕疙瘩中国家系以青春期自发发病为主,好发于胸背肩部,常呈对称发病,且各有其独特的形状,临床表型存在个体差异和不完全外显,并呈现出逐代减轻之趋势。结论:瘢痕疙瘩中国家系的遗传模式符合常染色体显性遗传,伴不完全外显,并且存在表现度差异;家系发病有其独特的相似之处,与散发瘢痕疙瘩病例相比存在许多差异。

Characteristics of occurrence for Chinese familial keloids

Objective To study the characteristics of occurrence for Chinese familial keloids.Methods To search their corporate characteristics of occurrence by collecting the clinical information from six Chinese keloid families among which there was no relationship.Results The keloids of these families mainly occur spontaneously during adolescence,predispose to display at chest,back and shoulder with respective specific figures and variable clinical expression,showing the trend to alleviate gradually,present incomplete clinical penetrance,and often appear symmetrically.Conclusion The pattern of inheritance observed in these Chinese keloid families is consistent with an autosomal dominant mode with incomplete clinical penetrance and variable expression.The keloids of these families arise with many particular similar features differing from those of sporadic cases.