干姜、炮姜对大鼠实验性胃溃疡的影响

报告了干姜、炮姜水煎液按4.5g/kg灌胃对大鼠4种实验性胃溃疡模型的影响,结果表明:炮姜除消炎痛模型外,对其他3种溃疡模型均呈明显的抑制倾向,干姜则无此作用。急性毒性试验显示:炮姜LD₅₀为170.6±1.1g/kg,干姜250g/kg以上未见死亡。提示:干姜经砂炒炮制后的炮姜,水溶性成分发生了变化。

Effect of Dry Ginger and Roasted Ginger on Experimental Gastric Ulcers in Rats

This paper reports the effect of dry ginger and roasted ginger decoctions on four experimental gastric ulcer models in rats at an oral administration of 4.5g/kg. The result shows that the roasted ginger has an obvious inhibiting tendency on three gastric ulcer models except the indomethaciu induced model while the dry ginger has no such effects. The acute toxicity test has shown that the LD₅₀ of roasted ginger decoction administered orally is 170.6±1.1g/kg, but it is over 250g/kg with dry ginger. This suggests that the ware soluble constituents of the dry ginger have changed in the roasting process.