Determination of Clara cell protein urinary elimination as a marker of tubular dysfunction |
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Authors: | Ascensión Martín-Granado Carmen Vázquez-Moncholí María Isabel Luis-Yanes Marisela López-Méndez Víctor García-Nieto |
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Institution: | 1.Laboratory Service,Hospital Nuestra Se?ora de Candelaria,Canary Islands,Spain;2.Pediatric Nephrology Unit,Hospital Nuestra Se?ora de Candelaria,Canary Islands,Spain |
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Abstract: | Clara cell 16-kDa protein (CC16) is a protein expressed primarily by the bronchial cells. It is rapidly eliminated by glomerular
filtration, reabsorbed almost entirely, and catabolized in proximal tubule cells. To date, normal values for urinary CC16
in healthy children have not been determined. We have studied 63 pediatric patients (mean age 8.17 ± 3.91 years) and 31 healthy
children (control group; mean age 8.83 ± 3.65 years). In the control group, the CC16/creatinine ratio was 1.22 ± 1.52 μg/g.
In 16 out of 31 control children, the value of the ratio was zero. Fourteen patients (22.2%) showed a high CC16/creatinine
ratio; in contrast, among these same patients, the ratio N-acetyl-β-d-glucosaminidase (NAG)/creatinine was elevated in seven cases (11.1%) and the ratio β2-microglobulin/creatinine was elevated
in seven cases (11.1%). The three parameters were in agreement in 51 patients (80.9%). Among the patients, the CC16/creatinine
ratio was correlated with both the β2-microglobulin/creatinina ratio (r = 0.76, P < 0.001) and the NAG/creatinine ratio (r = 0.6, P < 0.001). Our findings indicate that CC16 is a good marker of proximal tubular function in childhood. The highest observed
values were in children with proximal tubulopathies, in children with chronic renal failure, and in those treated with cyclosporine. |
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Keywords: | Clara cell protein Chronic renal failure Cyclosporine A Hypercalciuria Hypocitraturia Tubular proximal dysfunction |
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