Avidity of Antibodies against Infecting Pneumococcal Serotypes Increases with Age and Severity of Disease |
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| Authors: | Amelieke J. H. Cremers Jonneke Lut Peter W. M. Hermans Jacques F. Meis Marien I. de Jonge Gerben Ferwerda |
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| Affiliation: | aLaboratory of Pediatric Infectious Diseases, Department of Pediatrics, Radboudumc, Nijmegen, The Netherlands ;bDepartment of Medical Microbiology and Infectious Diseases, Canisius Wilhelmina Hospital, Nijmegen, The Netherlands ;cDepartment of Medical Microbiology, Radboudumc, Nijmegen, The Netherlands |
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| Abstract: | ![]()
The incidence of invasive pneumococcal disease (IPD) rises with age. Among adult IPD patients, the avidity of antipneumococcal polysaccharide antibodies against the infecting serotype increased with age and severity of disease, indicating that susceptibility to IPD in the elderly may rather be due to flaws in other aspects of opsonophagocytosis. |
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