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| 血管紧张素转换酶抑制剂对肺循环的作用 | |
| 引用本文： | 张德明 邹霞英. 血管紧张素转换酶抑制剂对肺循环的作用[J]. 中华结核和呼吸杂志, 1994, 17(6): 369-371 |
| 作者姓名： | 张德明 邹霞英 |
| 作者单位： | 广州军区总医院 |
| 摘 要： | 研究了新的非巯基类血管紧张素转换酶抑制剂──Ｃｉｌａｚａｐｒｉｌ对肺心病大鼠肺动脉高压及低氧血症的作用。大鼠常压间歇缺氧并静脉注射三氯化铁４周后，肺动脉平均压（ｍＰＡＰ）显著升高，动脉血氧分压（ＰａＯ＿２）显著下降，形成了与肺心病相似的肺动脉高压（ＰＨ）并低氧血症的模型。若每次缺氧前预用Ｃｉｌａｚａｐｒｉｌ０．５ｍｇ／只，能显著防止肺动脉压（ＰＡＰ）升高和ＰａＯ＿２下降，部分逆转右心肥大，减轻肿瘤坏死因子（ＴＮＦ）及氧自由基对肺的损伤。 |
| 关 键 词： | 缺氧，高血压，肺性，低氧血症 |
The protective effects of Cilazapril on chronic hypoxicpulmonary hypertension and hypoxemia in rats. |
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| ZhangDeming, Zou Xiaying, Xin Da lin,et al.. The protective effects of Cilazapril on chronic hypoxicpulmonary hypertension and hypoxemia in rats.[J]. Chinese journal of tuberculosis and respiratory diseases, 1994, 17(6): 369-371 | |
| Authors: | ZhangDeming Zou Xiaying Xin Da lin et al. |
| Affiliation: | ZhangDeming, Zou Xiaying, Xin Da lin, et al. |
| Abstract: | his study attempted to research the protective ef-fects of cilazapril, a new ACE inhibitor, on chronic hy-poxic pulmonary hypertension and hypoxemia in rats.The mean pulmonary arterial pressure (mPAP) of therats after hypoxia and injection with 1% Fecl_3 via thetail veins for 4 weeks increased significantly but its PaO_2decreased separately. Cilazapril effectively protectedmPAP increase and PaO_2 decrease in rats treated withCilazapril (0. 5mg/d) by surpressing the lung injury ofTNF and oxygen free radical. |
| Keywords: | Hypoxia Hypertension Pulmonary Hypoxemia |
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