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| 维拉帕米改善实验性沙土鼠脑缺血后LCBF和脑水份含量 | |
| 引用本文： | 张晨 包仕尧. 维拉帕米改善实验性沙土鼠脑缺血后LCBF和脑水份含量[J]. 中国药理学通报, 1991, 7(4): 283-286 |
| 作者姓名： | 张晨 包仕尧 |
| 作者单位： | 苏州医学院附二院脑循环研究室 江苏215004(张晨，包仕尧)，苏州医学院附二院脑循环研究室 江苏215004(赵合庆) |
| 摘 要： | 利用沙土鼠脑缺血再灌注模型,于缺血前或缺血后静脉注入钙通道阻滞剂维拉帕米0.5mg/kg,结果表明,维拉帕米显著地改善沙土鼠脑缺血后低灌注现象,增加缺血区脑血流量(P<0.01),同时减轻脑水份含量(P<0.01),对脑缺血后神经细胞将起保护作用,值得进一步研究及临床验证。 |
| 关 键 词： | 钙通道阻滞剂 脑缺血 局部脑血流量 蒙古沙土鼠 维拉帕米 |
VERAPAMIL IMPROVES LOCAL CEREBRAL BLOOD FLOW AND BRAIN WATER CONTENT AFTER CEREBRAL ISCHEMIA IN GERBIL |
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| Zhang Chen,Bao Shirao,Zhao Heqin. VERAPAMIL IMPROVES LOCAL CEREBRAL BLOOD FLOW AND BRAIN WATER CONTENT AFTER CEREBRAL ISCHEMIA IN GERBIL[J]. Chinese Pharmacological Bulletin, 1991, 7(4): 283-286 | |
| Authors: | Zhang Chen Bao Shirao Zhao Heqin |
| Abstract: | The gerbil model in this study was induced by 30 min of bilateral carotid occlusion and 120 min of reperfusion. Verapamil ( 0.5 mg/kg)was given intravenously 10 min before ischemia, or 5 min after bilateral carotid occlusion. Local cerebral blood flow was determined by the hydrogen clearance teachnique. Brain water content was detected by the wet and dry methods. We conclude that verapamil used in this model may improve post-ischemic hypo-perfusion, increase local cerebral blood flow in ischemic region (P< 0.01 ) , and reduce brain water content ( P<0.01 ). Verapamil has a protective effect on post-ischemic neurol damage. |
| Keywords: | Calcium channel blocker Cerebral ischemia Local cerebral blood flow Mongolian gerbil Verapamil |
| 本文献已被 CNKI 维普 等数据库收录！ | |