| 多西环素牙周缓释凝胶的配方筛选研究 |
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| 引用本文： | 郑怀宇a,谢静忠b,彭彩秀a. 多西环素牙周缓释凝胶的配方筛选研究[J]. 中国现代应用药学, 2007, 24(6): 484-486 |
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| 作者姓名： | 郑怀宇a 谢静忠b 彭彩秀a |
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| 作者单位： | 1. 浙江舟山医院,药剂科,浙江,舟山,316004
2. 浙江舟山医院,口腔科,浙江,舟山,316004 |
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| 摘 要： | 目的探索一种牙周缓释凝胶的最佳配方。方法将聚乳酸-乙醇酸共聚物(PLGA)浓度、溶剂配比和多西环素浓度按三个水平作正交设计,进行体外释放度试验,以第6天的释放百分率和凝结时间的综合分为指标,计算极差。结果按极差大小,PLGA浓度>溶剂配比>多西环素浓度,最佳配方为PLGA浓度15%,1MP:GTA=7:3,多西环素浓度为6%。结论用正交设计进行配方筛选是一种较好的试验方法。
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| 关 键 词： | 缓释凝胶 聚乳酸-乙醇酸共聚物 多西环素 正交设计 |
| 文章编号： | 1007-7693（2007）06-0484-03 |
| 收稿时间： | 2006-09-25 |
| 修稿时间： | 2006-09-25 |
Formula Screening Study on Periodontal Sustained-release Gel with Doxycycline |
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| ZHENG Huai-yu,XIE Jing-zhong,PENG Cai-xiu a. Formula Screening Study on Periodontal Sustained-release Gel with Doxycycline[J]. The Chinese Journal of Modern Applied Pharmacy, 2007, 24(6): 484-486 |
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| Authors: | ZHENG Huai-yu XIE Jing-zhong PENG Cai-xiu a |
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| Abstract: | OBJECTIVE To explore a best formula of sustained-released gel.METHODS Made an orthogonal design at 3 levels of 3 factors(concentration of PLGA,portion of solvent and concentration of doxycycline) to measure the concentration of doxycycline in vitro,caculated the range using the releasing rate on the sixth day and score of coagulate time as parameter.RESULTS According to the range,PLGA's concentration >solvent's portion>doxycycline's concentration,the best formula was:the concentration of PLGA80:20 =15%(w/w),1MP:GTA=7:3 and doxycycline concentration=6 %(w/w).CONCLUSION It is a good screening method to find out the best formula by orthogonal design. |
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| Keywords: | sustained-released gel PLGA doxycycline orthogonal design |
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