| SPERMIDINE RADIOIMMUNOASSAY IN MONITOR OF PRECANCEROUS LESIONS OF ESOPHAGUS |
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| 作者姓名： | 范振符 陈智周 林培中 张金生 刘昌佑 苏平 |
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| 作者单位： | Cancer Institute，Chinese Academy of Medical Sciences，Beijing，Cancer Institute，Chinese Academy of Medical Sciences，Beijing，Cancer Institute，Chinese Academy of Medical Sciences，Beijing，Cancer Institute，Chinese Academy of Medical Sciences，Beijing，Cancer Institute，Chinese Academy of Medical Sciences，Beijing，Cancer Institute，Chinese Academy of Medical Sciences，Beijing |
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| 摘 要： | Serum spermidine was assayed by radioimmuno-assay in different stages of esophageal carcinogenesis in the population from high risk area of esophageal cancer, Linxian County. The serum spermidine values were 76.94 74.38 ng ml in 36 normal individuals; 115.71 113.45 ng/ml in 35 patients with marked epithelial hyperplasia (MEH) and 294.48 135.36 ng/ml in 31 patients with early esophageal cancer. Patients with MEH were given intervention treatment by Aminoretinoic Ester or Anticancer B or placebo (starch) as controls. One year later, samples from the population were collected again for serum spermidine msasurement. The values were 95.8 68.2 ng/ml in 27 normals; 125.1±72.9 ng/ml in 62 patients with MEH treated by Anticancer B; 125.6± 117.2 ng/ml in 64 patients with MEH treated by Aminoretinoic Ester; 162.4±76.6 ng/ml in 62 controls and 210.5±182.9 ng/ml in 44 patients with early esophageal cancer.The results showed that spermidine radioim-munoassay could reflect the tendency of esophageal precancerous
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