脑缺血再灌注损伤对大鼠行为学的影响及中药作用机制

为研究脑缺血再灌注的发生机制及中药的作用效果，采用大鼠颈动脉反复缺血再灌注为动物模型。结果显示脑缺血再灌注后大鼠学习和记忆能力较对照组明显下降，MDA增高，SOD减低，而中药治疗组则相反，表明中药可通过其抗脂质过氧化作用，减轻脑缺血再灌注损伤。提示中药可具有抗自由基损伤的作用。

Abilities of learning andmemory of rats subjected to cerebral ischemia reperfusion injury and effect of Chinesemedicine on it

To investigate inpact of cerebral ischemia reperfusion on learning and memory and effect of Chinese medicine on it, the rat brain was subject to repeated ischemia reperfusion to develop the cerebral ischemia reperfusion model. Results showed that changes of learning and memory could be induced by repeated ischemia reperfusion, and treatment with Chinese medicine could significantly prevent ischemia reperfusion-induced memory deficiency at the dose of 4 g/(kg·d)(P.O). It was also shown that the content of SOD in brain decreased and MDA increased remarkably. The Chinese medicine can enhance the content of SOD and decrease the content of MDA, suggesting that it can modify the disorder of free radical system.