首页 | 本学科首页   官方微博 | 高级检索  
     


Association between Preoperative Long-Chain Polyunsaturated Fatty Acids and Oxidative Stress Immediately after Total Knee Arthroplasty: A Pilot Study
Authors:Yusuke Kubo  Masae Ikeya  Shuhei Sugiyama  Rie Takachu  Maki Tanaka  Takeshi Sugiura  Kaori Kobori  Makoto Kobori
Affiliation:1.Department of Rehabilitation, Kobori Orthopedic Clinic, 548-2 Nearaichou, Kita-ku, Hamamatsu 433-8108, Japan; (S.S.); (R.T.); (T.S.); (K.K.); (M.K.);2.Department of Health and Nutrition Sciences, Tokoha University, 1230, Miyakodachou, Kita-ku, Hamamatsu 431-2102, Japan;3.Rehabilitation Sciences, Seirei Christopher University, 3453 Mikataharachou, Kita-ku, Hamamatsu 433-8558, Japan;
Abstract:Quadriceps muscle atrophy following total knee arthroplasty (TKA) can be caused by tourniquet-induced ischemia–reperfusion (IR) injury, which is often accompanied by oxidative stress and inflammatory responses. n-3 long-chain polyunsaturated fatty acids (LCPUFAs), such as eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA), exert antioxidant and anti-inflammatory effects against IR injury, whereas n-6 LCPUFAs, particularly arachidonic acid (AA), exhibit pro-inflammatory effects and promote IR injury. This study aimed to examine whether preoperative serum EPA + DHA levels and the (EPA + DHA)/AA ratio are associated with oxidative stress immediately after TKA. Fourteen eligible patients with knee osteoarthritis scheduled for unilateral TKA participated in this study. The levels of serum EPA, DHA, and AA were measured immediately before surgery. Derivatives of reactive oxygen metabolites (d-ROMs) were used as biomarkers for oxidative stress. The preoperative serum EPA + DHA levels and the (EPA + DHA)/AA ratio were found to be significantly negatively correlated with the serum d-ROM levels at 96 h after surgery, and the rate of increase in serum d-ROM levels between baseline and 96 h postoperatively. This study suggested the preoperative serum EPA + DHA levels and the (EPA + DHA)/AA ratio can be negatively associated with oxidative stress immediately after TKA.
Keywords:arachidonic acid, docosahexaenoic acid, eicosapentaenoic acid, inflammation, ischemia–  reperfusion injury, muscle atrophy, oxidative stress, polyunsaturated fatty acids, tourniquet use, total knee arthroplasty
设为首页 | 免责声明 | 关于勤云 | 加入收藏

Copyright©北京勤云科技发展有限公司  京ICP备09084417号