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Nuclear inclusion bodies of mutant and wild‐type p53 in cancer: a hallmark of p53 inactivation and proteostasis remodelling by p53 aggregation
Authors:Daphne Hompes  Evelyne Naus  Greet De Baets  Tobias Langenberg  Mark S Hipp  Bert Houben  Filip Claes  Sarah Charbonneau  Javier Delgado Blanco  Stephane Plaisance  Shakti Ramkissoon  Lori Ramkissoon  Colinda Simons  Piet van den Brandt  Matty Weijenberg  Manon Van England  Sandrina Lambrechts  Frederic Amant  André D'Hoore  Keith L Ligon  Xavier Sagaert  Joost Schymkowitz  Frederic Rousseau
Affiliation:1. Department of Abdominal Surgery, University Hospitals Gasthuisberg, Leuven, Belgium;2. The Switch Laboratory, Department of Cellular and Molecular Medicine, KU Leuven, Leuven, Belgium;3. VIB Center for Brain and Disease Research, Leuven, Belgium;4. Department of Cellular Biochemistry, Max Planck Institute of Biochemistry, Martinsried, Germany;5. Department of Medical Oncology, Center for Molecular Oncologic Pathology, Dana‐Farber Cancer Institute, Boston, MA, USA;6. Nucleomics Core, Flanders Institute for Biotechnology (VIB), Leuven, Belgium;7. Department of Pathology, Division of Neuropathology, Brigham and Women's Hospital and Children's Hospital Boston, Boston, MA, USA;8. Department of Pathology, Harvard Medical School, Boston, MA, USA;9. Department of Epidemiology 10. – 11. GROW School for Oncology and Developmental Biology, Maastricht University, Maastricht, The Netherlands;12. Department of Pathology 13. Department of Obstetrics and Gynaecology, Division of Gynaecological Oncology, University Hospitals Leuven, KU Leuven, Leuven, Belgium;14. Centre for Gynaecological Oncology Amsterdam, Netherlands Cancer Institute, Amsterdam, The Netherlands;15. The Broad Institute, Cambridge, MA, USA;16. Department of Pathology, Children's Hospital Boston, Boston, MA, USA;17. Translational Cell and Tissue Research, KU Leuven, Leuven, Belgium
Abstract:
Keywords:p53 aggregation  proteostasis  colon cancer  glioblastoma  nuclear inclusion bodies
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