| 绞股蓝及单体Rb_1对小鼠学习记忆的促进作用 |
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| 引用本文： | 常蜀英,匡培根,张均田,陈延镛,俞承明.绞股蓝及单体Rb_1对小鼠学习记忆的促进作用[J].中国药理学通报,1988(6). |
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| 作者姓名： | 常蜀英 匡培根 张均田 陈延镛 俞承明 |
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| 作者单位： | 解放军总医院 北京解放军军区进修学院八四级研究生空军总医院神经内科
(常蜀英)，解放军总医院 北京
(匡培根)，中国医学科学院药研所 北京
(张均田，陈延镛)，广州军区药检所 广州(俞承明) |
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| 摘 要： | 采用一次性被动回避条件反应—跳台法及避暗法的行为实验和5种化学药物所致记忆障碍的模型,观察了葫芦科植物绞股蓝的3种提取剂及单体Rb_1对小鼠学习记忆的影响。结果表明绞股蓝3种提取剂均可改善樟柳碱引起的记忆获得障碍;Rb_1可对抗30％乙醇和戊巴比妥钠所致记忆获得障碍;绞股蓝20％醇提剂对蛋白合成抑制剂(环已酰亚胺、氯霉素)造成的记忆巩固不良以及20％乙醇引起的记忆再现障碍均有拮抗作用。
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| 关 键 词： | 绞股蓝 绞股蓝皂甙Rb_1 学习记忆 |
MEMORY FACILITATION INDUCED BY GYNOSTEMMA PENTAPHYLLUM AND GYPENOSIDE Ⅲ ( GINSENOSIDER b_1 ) IN MICE |
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| Chang Shuying,Kuang Peigen et al.MEMORY FACILITATION INDUCED BY GYNOSTEMMA PENTAPHYLLUM AND GYPENOSIDE Ⅲ ( GINSENOSIDER b_1 ) IN MICE[J].Chinese Pharmacological Bulletin,1988(6). |
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| Authors: | Chang Shuying Kuang Peigen |
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| Abstract: | Aquatic, 20% alcoholic & 95% alcoholic extractions of the aeri -al parts of Gynostemma pentaphyllum from Guangdong Provin -ce contain several gypenosides as same as some ginsenosides. The effects of the extractions and gypenoside Ⅲ (ginsenoside Rb 1 ) on memory in mice were studied using one trial passive avoidance responses. Results indicated that Gynostemma pentaphyllum improved impairment of acquisition of memory produced by anisodine, and disruption of consolidation of memory caused by cycloheximide and chlo-ramphenicol. Gynostemma was capable of antagonizing alcoh cl-induc- ed deficit of retrieval. Similar effects were observed with Rb1 in the impairments of acquisition of memory caused by alcohol and pen-tobarbitone sodium. It is clear that Gynostemma pentaphyllum may be an effective memory-enhancing agent. |
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| Keywords: | Gynostemma pentaphyllum Gypenoside Rbl Learning and Memory |
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