| 74例三阴性乳腺癌临床特征及预后分析 |
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| 引用本文： | 王蓓,傅健飞,吕晓皑. 74例三阴性乳腺癌临床特征及预后分析[J]. 肿瘤学杂志, 2009, 15(11) |
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| 作者姓名： | 王蓓 傅健飞 吕晓皑 |
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| 作者单位： | 浙江省中医院,浙江,杭州,310006 |
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| 摘 要： | [目的]探讨三阴性乳腺癌的临床病理特征、复发及预后。[方法]回顾性分析2000年7月至2006年7月手术治疗的486例乳腺癌患者资料。将ER、PR、HER-2均为阴性患者定义为三阴性乳腺癌组,其他患者定义为非三阴性乳腺癌组。采用免疫组化法检测ER、PR、HER-2的表达,随访观察患者的生存情况。74例(15.2%)符合三阴性乳腺癌诊断标准。[结果]与非三阴性乳腺癌组比较,三阴性乳腺癌组绝经前患者比例升高,组织学分级较高。三阴性乳腺癌组5年无病生存率、5年总生存率均低于非三阴性乳腺癌组(P=0.038,P=0.014)。且三阴性乳腺癌患者更容易出现内脏转移(P=0.024),复发后生存时间更短(P=0.000)。[结论]三阴性乳腺癌患者有着特殊的临床病理特征,易出现复发转移(尤其是内脏转移),预后差。
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| 关 键 词： | 乳腺肿瘤 ER PR Her-2 预后 |
Clinical Features and Prognostic Analysis of 74 Cases with Triple-negative Breast Cancer |
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| WANG Bei,FU Jian-fei,LV Xiao-ai. Clinical Features and Prognostic Analysis of 74 Cases with Triple-negative Breast Cancer[J]. Journal of Chinese Oncology, 2009, 15(11) |
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| Authors: | WANG Bei FU Jian-fei LV Xiao-ai |
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| Affiliation: | WANG Bei; FU Jian-fei; LV Xiao-ai (Zhejiang Provincial Hospital of TCM; Hangzhou 310006; China); |
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| Abstract: | [Purpose] To investigate of the clinical pathological features, recurrence and prognosis of triple-negative breast cancer. [Methods] From July 2000 to July 2006, 486 cases of breast cancer with surgical treatment were analyzed retrospectively. The triple-negative breast cancer is defined as negative expression of estrogen receptor(ER), progesterone receptor (PR) and HER-2, and the other cases were non-triple-negative. The expression of ER, PR and HER-2 were detected by immunohistochemical method. All the ca... |
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| Keywords: | ER PR Her-2 |
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