| Effects of valsartan on oxidative stress and the atherogenesis |
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| 引用本文： | 陈钧,王琳,陈欣,卜军,刘念,阮燕菲. Effects of valsartan on oxidative stress and the atherogenesis[J]. 中国人民解放军军医大学学报, 2003, 18(6): 345-348 |
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| 作者姓名： | 陈钧 王琳 陈欣 卜军 刘念 阮燕菲 |
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| 作者单位： | Cardiovascular Department，Tongji Hospital，Tongji Medical College，Huazhong University of Science and Technology，Wuhan 430030，China，Cardiovascular Department，Tongji Hospital，Tongji Medical College，Huazhong University of Science and Technology，Wuhan 430030，China，Cardiovascular Department，Dongfeng Motor Corporation Hospital，Shiyan 442000，China，Cardiovascular Department，Tongji Hospital，Tongji Medical College，Huazhong University of Science and Technology，Wuhan 430030，China，Cardiovascular Department，Tongji Hospital，Tongji Medical College，Huazhong University of Science and Technology，Wuhan 430030，China，Cardiovascular Department，Tongji Hospital，Tongji Medical College，Huazhong University of Science and Technology，Wuhan 430030，China |
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| 摘 要： | Introduction Oxidativestressandtheproductionofintracellularreactiveoxygenspecies (ROS)havebeenimplicatedinthepathogenesisofatherosclero sis[1] .ROSandtheirbyproductsnotonlymaybecyto toxictocellsbutalsoplayaroleinsignaltransductionprocessessuchascell growthandposttranslationalmodificationofproteinswhichwillcontributetotheformationofatherosclerosis[2 ] .EarlystudiesreportedthattheactivationofAngiotensinⅡtypeⅠreceptorisinvolvedintheoxidativestress :ItnotonlyspecificallyactivatesNAD(P)Hoxi…
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| 关 键 词： | 缬沙坦 动脉粥样硬化 抗氧化 动物实验 细胞粘附因子 免疫组织化学 |
Effects of valsartan on oxidative stress and the atherogenesis |
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| CHEN Jun,WANG Lin,CHEN Xin,PU Jun LIU Nian,RUAN Yan-fei Cardiovascular Department,Tongji Hospital,Tongji Medical College,Huazhong University of Science and Technology,Wuhan ,China Cardiovascular Department,Dongfeng Motor Corporation Hospital,Shiyan ,China. Effects of valsartan on oxidative stress and the atherogenesis[J]. Journal of Medical Colleges of PLA(China), 2003, 18(6): 345-348 |
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| Authors: | CHEN Jun WANG Lin CHEN Xin PU Jun LIU Nian RUAN Yan-fei Cardiovascular Department Tongji Hospital Tongji Medical College Huazhong University of Science Technology Wuhan China Cardiovascular Department Dongfeng Motor Corporation Hospital Shiyan China |
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| Affiliation: | CHEN Jun,WANG Lin,CHEN Xin,PU Jun LIU Nian,RUAN Yan-fei 1Cardiovascular Department,Tongji Hospital,Tongji Medical College,Huazhong University of Science and Technology,Wuhan 430030,China 2Cardiovascular Department,Dongfeng Motor Corporation Hospital,Shiyan 442000,China |
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| Abstract: | Objective: To investigate the therapy effect of valsartan on oxidative stress and the formation of atherosclerosis of rabbit. Methods: An atherosclerotic rabbit model was established by feeding high cholesterol diet supplemented by bovine serum albumin injection bolus. The rabbits were randomly divided into the control, model, and valsartan treated group, six rabbits in each group. Blood samples were collected at the end of 8 weeks for examination of serum lipid levels and MDA levels; the aortas were harvested for histological morphometry analysis, vascular cell adhesion molecule-1 (VCAM-1) immunohistochemical analysis and in situ superoxide detection to reflect the activity of NAD(P)H oxidase. Results: Rabbits fed with high cholesterol diet showed higher serum lipids levels than those fed with normal diet(P<0.01). Treatment with valsartan (10 mg/kg per day) did not alter serum lipids levels. But the serum MDA level and ratio of lesion to intima area reduced significantly compared with model group(P<0.05). The expression of VCAM-1 decreased significantly in the valsartan treated group than in the model group (P<0.05).In addition, in situ superoxide detection also show the markedly reduction of superoxide as a result of valsartan treatment. Conclusion: These results indicate that the valsartan treatment can reduce the atherosclerotic progression, the mechanisms of which may include the inhibiting the NAD(P)H oxidase activity to produce superoxide and the downregulating the expression of redox sensitive genes in the downstream, such as VCAM-1. |
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| Keywords: | valsartan atherosclerosis oxidative stress NAD(P)H oxidase |
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