Characterization of the human effector cell causing antibody-mediated cytotoxicity

Human peripheral mononuclear cells were used as effector cells in antibody-mediated cytotoxicity. Chicken and sheep erythrocytes coated with antibody were used as target cells.

The nature of the effector cell was characterized by different in vitro methods of cell separation. It is concluded that both monocytes and lymphocytes are cytotoxic in this system. The lymphocyte appears to have a receptor for the Fc part of immunoglobulin but lacks detectable surface immunoglobulin.