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联合检测血清CA125、CA199、CA153和CA724对卵巢癌的诊断价值
引用本文:李宜川,芦琨,赵炎. 联合检测血清CA125、CA199、CA153和CA724对卵巢癌的诊断价值[J]. 中国妇幼保健, 2012, 27(2): 271-273
作者姓名:李宜川  芦琨  赵炎
作者单位:1. 商丘医学高等专科学校生物化学教研室 河南商丘 476000
2. 河南省商丘市 妇幼保健院
摘    要:
目的:探讨肿瘤标志物CA125、CA199、CA153和CA724联合检测对卵巢癌的诊断价值。方法:采用电化学发光法测定45例卵巢癌患者、38例卵巢良性肿瘤患者和41例健康妇女血清中的CA125、CA199、CA153和CA724水平。结果:卵巢癌患者血清CA125、CA199和CA153水平显著高于正常对照组(P<0.05);卵巢癌患者血清CA125、CA199和CA153阳性率分别为66.6%、31.1%和42.2%,均显著高于正常对照组(P<0.05);联合检测CA125、CA199、CA153和CA724诊断卵巢癌的阳性率为86.6%,诊断卵巢良性肿瘤的阳性率为34.2%,均显著高于正常对照组(P<0.05),且显著高于单一肿瘤标志物检测的阳性率;联合检测的敏感性(86.6%)和准确性(91.5%)均高于单项检测结果。结论:联合检测CA125、CA199、CA153和CA724对卵巢恶性肿瘤的诊断和鉴别具有重要意义。

关 键 词:卵巢癌  CA125  CA199  CA153  CA724  联合

Diagnostic value of combined detection of serum CA125,CA199,CA153,and CA724 for ovarian cancer
LI Yi-Chuan , LU Kun , ZHAO Yan. Diagnostic value of combined detection of serum CA125,CA199,CA153,and CA724 for ovarian cancer[J]. Maternal and Child Health Care of China, 2012, 27(2): 271-273
Authors:LI Yi-Chuan    LU Kun    ZHAO Yan
Affiliation:.Department of Biochemistry,Shangqiu Medical College,Shangqiu 476000,He’nan,China
Abstract:
Objective:To explore the diagnostic value of combined detection of tumor markers(CA125,CA199,CA153,and CA724) for ovarian cancer.Methods:Electrochemiluminescence method was used to detect the serum levels of CA125,CA199,CA153,and CA724 in 45 patients with ovarian cancer,38 patients with benign ovarian tumor,and 41 healthy women.Results:The serum levels of CA125,CA199,and CA153 in ovarian cancer group were significantly higher than those in normal control group(P<0.05);the positive rates of CA125,CA199,and CA153 in ovarian cancer group were 66.6%,31.1%,and 42.2%,respectively,which were significantly higher than those in normal control group(P<0.05);the positive rates of combined detection of serum CA125,CA199,CA153,and CA724 for diagnosis of ovarian cancer and benign ovarian tumor were 86.6% and 34.2%,respectively,which were significantly higher than those in normal control group(P<0.05),and they were significantly higher than those of single tumor marker detection;the sensitivity(86.6%) and accuracy(91.5%) of combined detection was higher than those of single tumor marker detection.Conclusion:The combined detection of CA125,CA199,CA153,and CA724 has important significance for diagnosis and differential diagnosis of malignant ovarian tumor.
Keywords:Ovarian cancer  CA125  CA199  CA153  CA724  Combination
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