深圳妇女人乳头瘤病毒感染状况与宫颈病变相关性研究

目的:探讨深圳地区妇女宫颈人乳头瘤病毒(human papillomavirus,HPV)感染分布情况及主要型别,为深圳地区临床宫颈癌的防治、研制适合该地区的预防性HPV疫苗提供理论依据。方法:对2010年11月～2011年8月至该院妇科行宫颈癌筛查的1 800例妇女行液基细胞学检查和HPV检测,对HPV阳性病例均行阴道镜下多点活体组织检查(活检),对其HPV感染状况,所感染的HPV亚型分布以及与病变程度间的关系进行分析和总结。结果:1 800例标本中检查出HPV阳性病例379例,感染率为21.06%。深圳妇女在40岁以后HPV感染率下降。单一HPV感染的有335例,占88.39%,2种以上的多重HPV感染共44例,占11.61%。单一感染和双重以上感染其引起的高度宫颈上皮内瘤变(cervical in intraepithelial neoplasia,CIN)及宫颈癌的发病率,两组之间差别无统计学意义(P>0.05)。常见的基因型高危型由高至低依次是52、16、58、56、33,低危型依次是43、42、6、11。结论:深圳妇女宫颈HPV感染亚型常见的是高危型52、16、58、56、33,低危型是43、42、6、11。其中引起高度CIN和宫颈癌的HPV亚型主要是16、33、52、58。

Study on the correlation between current situation of human papillomavirus infection and cervical lesions among the women in Shenzhen city

Objective:To explore the distribution and main types of human papillomavirus(HPV) infection among the women in Shenzhen city,provide a theoretical basis for prevention and treatment of cervical cancer and developing prophylactic HPV vaccine suitable for the women in Shenzhen city. Methods:A total of 1 800 women receiving cervical cancer screening in gynecological department of the hospital from November 2010 to August 2011 underwent liquid-based cytological test and HPV detection,the positive cases received multi-point biopsy under colposcope,the relationship between HPV infection status,distribution of HPV subtypes and the degree of the diseases was analyzed and summarized. Results:Among 1 800 cases,379 cases were found with positive HPV,the infection rate was 21.06%.The infection rate of HPV among the women more than 40 years old decreased in Shenzhen city.A total of 335 cases were found with single HPV infection,accounting for 88.39%;44 cases were found with multiple HPV infection,accounting for 11.61%.There was no significant difference in the incidences of cervical intraepithelial neoplasia(CIN) Ⅲ and cervical cancer between the cases with single HPV infection and the cases with multiple HPV infection(P>0.05).The common genotypes of high risk HPV from high to low were 52,16,58,56,and 33;the common genotypes of low risk HPV from high to low were 43,42,6,and 11. Conclusion:Among the women in Shenzhen city,the common high risk HPV subtypes are 52,16,58,56,and 33;the common low risk HPV subtypes are 43,42,6,and 11.The main HPV subtypes inducing CIN Ⅲ and cervical cancer are 16,33,52,and 58.