支原体感染与女性不孕不育的关系以及相关支原体耐药性分析

目的:探索支原体感染与女性不孕不育的关系。方法:选择2010年1月～2010年12月226例女性不孕不育患者,采集患者宫颈分泌物进行支原体培养,对阳性组进行药效试验,并选择敏感抗菌药进行治疗。结果:阳性组患者输卵管通畅者构成比为35.2%,显著低于阴性组(P<0.05);而输卵管通而不畅和输卵管堵塞构成比分别为22.9%和41.9%,显著高于阴性组(P<0.05)。阳性组不孕时间显著长于阴性组(P<0.05);且NK细胞比例显著高于阴性组(P<0.05)。交沙霉素耐药发生率最低,为1.0%。结论:支原体感染和女性不孕不育发病具有相关性,不同地区的支原体感染者药物敏感性存在差别,为获得理想的治疗效果,应依据药敏试验结果选择抗菌药物。

Analysis of the relationship between mycoplasma infection and female infertility and related drug resistance of mycoplasma

Objective:To study the relationship between mycoplasma infection and female infertility.Methods:The 226 patients with female infertility were selected in our department from January to December 2010.According to the laboratory test results,105 cases of positive patients were taken as positive group,and 121 cases of negative patients were taken as negative group.Results:The proportion of oviduct tubes of positive group was 35.2%,and was significantly lower than negative group(P<0.05),while the proportion of jammed tubes and blockage tubal of positive group was respectively 22.9% and 41.9%,and was significantly higher than negative group(P<0.05).The infertility time of positive group was significantly longer than negative group(P<0.05),and the proportion of NK cell of positive group was significantly higher than negative group(P<0.05).The resistance rates of Josamycin was the lowest(1.0%).Conclusion:Mycoplasma infection was associated with the incidence of female infertility.The sensitivity of mycoplasma infection drugs is differences in different parts.In order to obtain the desired therapeutic effect,antibiotics should be selected based on susceptibility testing.