肺癌组织OSE表达及其与临床病理因素相关性的探讨

目的：探讨胱硫醚7裂解酶（cystathi—onine γ—lyase，CSE）在肺癌中的表达及临床意义。方法：应用免疫组织化学方法检测40例肺癌组织中CSE和以CD34为标记的微血管密度（MVD）的表达情况。采用SPSS17．0统计软件进行统计学处理，用x2检验对计数资料进行统计学分析，对于计量资料实验结果用x±s表示，以两纽之间采用非匹配t检验。结果：肺癌组织标本中CSE的表达阳性率（75％）明显高于正常肺组织阳性率（25％），并与肿瘤大小（x2=9．404，P=0．020）及分化程度（x2=6．078，P=0．048）相关；MVD在肺癌组织的表达为43．60±7．57，明显高于正常组织（30．25±7．61），两者经统计学分析t=7．314，P=0．00，差异有统计学意义。MVD与肿瘤大小、分化程度及TNM分期相关，P〈0．05。CSE与MVD两者呈正相关，t=3．65，P=0．010。结论：CSE参与了肿瘤的血管新生过程，可能对促进肺癌的发生和发展具有重大意义。

Expression of OSE in lung cancer tissues and discussions of OSE with clinical relevant factors

OBJECTIVE： To investigate the expression and clinical significance of CSE in lung cancer. METHODS： Immu nohistochemistry SP method was used to detect the expressions of CSE and MVD who was marked by CD34. Using SPSS17.0 statistical software for statistical analysis, 2 test for measure ment data and not matched t-test for enumeration data between two groups, and the results were showed by x^- ＋- s for enumera tion data. RESULTS： The positive rate of CSE in lung cancer specimens （75%）was significantly higher than that of normal lung tissues（25%）, and was related to tumor size （x2 =9. 404, P=0. 020） and differentiation degree （x2 =6. 078, P=0. 048）. The expression of MVD in lung cancer was 43. 60 ＋- 7. 57, which significantly higher than that of normal lung tissues （30.25＋-7.61, t =7.314, P=0.000）, and MVDwere was related to tumor size, differentiation degree and TNM stages （P〈0. 05）. The expression of CSE was positive associated with the expression of MVD （t=3.65, P=0.010）. CONCLUSION ： CSE is involved in tumor angiogenesis process and is significant to promote the development and progression.