水通道蛋白1在乳腺癌组织中的表达及其意义

目的 探讨水通道蛋白1(AQP1)在乳腺癌组织中的表达和意义.方法 取乳腺癌组织40例及癌旁组织10例,应用RT-PCR法检测AQP1 mRNA在乳腺癌和癌旁组织中的表达及分布.结果 乳腺癌中AQP1 mRNA表达量(0.8957±0.0428),明显高于癌旁组织AQP1 mRNA表达量(0.3401±0.0549),差异有统计学意义(P＜0.05).结论 AQP1在乳腺癌组织中表达增高,提示AQP1可能与乳腺癌生长、转移有关.

Expression and significance of aquaporin-1 in breast carcinoma

Objective:To explore the expression  and the significance of aquaporin 1 (AQP1) in breast carcinoma tissues.
Methods:Specimcns of breast carcinoma tissues of 40 cases and the non-cancerous adjacent tissues of 10 cases were obtained immediately after surgery, and expression of aquaporin1 in htese tissues was examined by RT-PCR technique.
Results:AQP1 mRNA expression level in breast tumor tissues was 0.8957±0.0428, that in non-cancerous adjacent tissues was 0.3401±0.0549, and there was significant difference between them (P＜0.05).
Conclusions:The expression of AQP1 is increased in breast carcinoma tissues compared to normal breast tissues.It suggests that AQP1 may be related to the growth and metastasis of breast carcinoma.