甲钴胺、前列地尔联合依帕司他治疗糖尿病周围神经病变的临床疗效

目的观察甲钴胺、前列地尔联合依帕司他治疗糖尿病周围神经病变的临床疗效。方法选取120例确诊的糖尿病周围神经病变的患者为研究对象,随机分为观察组及对照组,每组各60例。观察组用钴胺、前列地尔联合依帕司他治疗,对照组用甲钴胺联合前列地尔治疗。观察两组患者的临床疗效及神经传导速度(MNCV和SNCV)变化。结果观察组总有效率90%;对照组总有效率75%,观察组明显优于对照组(P<0.05)。治疗后两组正中神经、腓总神经的感觉神经传导速度(SNCV)和运动神经传导速度(MNCV)较治疗前均有明显提高,差异有显著性(P<0.05);治疗后观察组神经传导速度较对照组有显著提高,差异有显著性(P<0.05)。结论甲钴胺、前列地尔联合依帕司他治疗糖尿病周围神经病变临床疗效好,可提高疗效。

The Clinical Effect of Mecobalamlne Combined with Alprostadil and Epalrestat on Diabetic Perineuropathy

Objective To investigate the Clinical effect of Mecobalamlne combined with Alprostadil and Epalrestat on Diabetic Perineuropathy.Methods 120 patients with diabetic were randomly divided into two groups,the observation group and the control group,there were 60 cases in each group.The observation group was treated with Mecobalamlne combined with Alprostadil and Epalrestat.While the control group was treated only with Mecobalarnine and Alprostadil.Then we observe the the Clinical effect and nerve conduction of the two methods.Results The total effective rate of observation group was 90%,while the total effective rate of control group was 75%.The Clinical effect of observation group was better than the control group（P〈0.05）.After treatment the sensory nerves conduction velocity（SNCV）and the motor nerves conduction velocity（MNCV）were obviously improved（P 0.05）.And the observation group more better than the control group after treated（P〈0.05）.Conclusion Mecobalamlne combined with Alprostadil and Epalrestat on Diabetic Perineuropathy had a better Clinical effect,and can improve the effi ciency.