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心肌炎患儿淋巴细胞凋亡的改变
引用本文:王文棣,蒋玉红,周冬,李秀真,孙裕平,马少春. 心肌炎患儿淋巴细胞凋亡的改变[J]. 中国当代儿科杂志, 1999, 1(1): 7-8
作者姓名:王文棣  蒋玉红  周冬  李秀真  孙裕平  马少春
作者单位:王文棣,蒋玉红,周冬,李秀真,孙裕平,马少春
摘    要:
目的 了解心肌炎患儿的淋巴细胞凋亡的改变,进一步探讨心肌炎的发病机理。方法 荧光法检测41例心肌炎患儿外周血淋巴细胞凋亡的改变,同时测定T淋巴细胞亚群与免疫球蛋白的变化。结果 心肌炎组淋巴细胞凋亡率高于正常组,且T淋巴细胞亚群CD4+,CD4+/CD8+明显下降,CD8+增高(P<0.01)。结论 淋巴细胞凋亡过度导致淋巴细胞总量失衡,T淋巴细胞及体液免疫功能均低下,可能是病毒或支原体感染后引起心肌炎的重要原因之一。

关 键 词:淋巴细胞  心肌炎  细胞凋亡  

Shift of apoptosis in lymphocyte in children with myocarditis
WANG Wen-Ti,JIANG Yu-Hong,ZHOU Dong,LI Xiu-Zhen,SUN Yu-Ping,MA Shao-Chun. Shift of apoptosis in lymphocyte in children with myocarditis[J]. Chinese journal of contemporary pediatrics, 1999, 1(1): 7-8
Authors:WANG Wen-Ti  JIANG Yu-Hong  ZHOU Dong  LI Xiu-Zhen  SUN Yu-Ping  MA Shao-Chun
Affiliation:WANG Wen-Ti, JIANG Yu-Hong, ZHOU Dong, LI Xiu-Zhen, SUN Yu-Ping, MA Shao-Chun
Abstract:
Objective To understand the shift of apoptosis in lymphocyte of children with myocarditis, to investigate the pathogenesis of myocarditis.Methods To detect the shift of apoptosis in T-lymphocyte by immunofluorescence among 41 children with myocarditis including infection of virus and mycoplasma, and the alteration of T-lymphocytic subgroup and immunoglobulin at the same time. Results The apoptosis of lymphocytes in myocarditis group was higher than that of normal group, and T-lymphocytic subgroup CD 4 +, CD 4 +/CD 8 + were distinctly descented, CD 8 + was elevated(P<0.01). Conclusions The excessive apoptosis of lymphocytes lead imbalance of the amount. The low functions of T-lymphocyte and humour immunity are one of the important cause of the myocarditis induced by the infection of virus or mycoplasma.
Keywords:Lymphocyte Myocarditis Apoptosis
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