| 胃癌多药耐药细胞株的建立及其生物学特征 |
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| 引用本文： | 蔡学君,张学庸,樊代明,王德堂. 胃癌多药耐药细胞株的建立及其生物学特征[J]. 中国肿瘤临床, 1994, 0(Z1) |
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| 作者姓名： | 蔡学君 张学庸 樊代明 王德堂 |
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| 作者单位： | 第四军医大学西京医院消化中心 西安市710032 |
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| 基金项目： | 国家自然科学基金第39270340号资助项目 |
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| 摘 要： | 胆囊癌的CEA免疫病理研究胆囊癌的CEA免疫病理研究胆囊癌的CEA免疫病理研究胆囊癌的CEA免疫病理研究胆囊癌的CEA免疫病理研究胆囊癌的CEA免疫病理研究胆囊癌的CEA免疫病理研究胆囊癌的CEA免疫病理研究胆囊癌的CEA免疫病理研究胆囊癌的CEA免疫病理研究胆囊癌的CEA免疫病理研究胆囊癌的CEA免疫病理研究胆囊癌的CEA免疫病理研究胆囊癌的CEA免疫病理研究胆囊癌的CEA免疫病理研究胆囊癌的CEA免疫病理研究胆囊癌的CEA免疫病理研究胆囊癌的CEA免疫病理研究胆囊癌的CEA免疫病理研究胆囊癌的CEA免疫病理研究胆囊癌的CEA免…
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| 关 键 词： | 胃肿瘤 多药抗药性 |
Establishment and Characteristics of Multidrug Resistant Human Stomach Cancer Cell Lines |
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| Cai Xue-Jun et al. Establishment and Characteristics of Multidrug Resistant Human Stomach Cancer Cell Lines[J]. Chinese Journal of Clinical Oncology, 1994, 0(Z1) |
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| Authors: | Cai Xue-Jun et al |
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| Affiliation: | Cai Xue-Jun et alDepartment of Gastroenterology,Xijing Hospital,4th Military Medical University,Xi-an |
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| Abstract: | Stomach cancer cell line SGC-7901 .selected by pulse treatment oi vincristine (VCR),were resistant to VCR and cross-resistant to MTX, 5-Fu,ADM, and MMC, but without resistance to CDDP. The resistance index were 65,24,372,1.7 and 4.9 respectively. The doubling time of the subline were prolonged and cell cycle changed. Chromosome banding analysis demonstrated gene amplification such as double minutes and homogeneously staining region in the short arm of chromosome 7 and heterozugous deletion of the long arm of chromosome 7, together with overexpression of P-glycoprotein, suggesting that this sub-line was classically multidrug resistant and could be an experimental model for study of resistant mechanism of stomach cancer and for new reversal method. |
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| Keywords: | Multidrug resistance Stomach cancer Cancer cell line |
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