| 荧光原位杂交技术在染色体异常中的应用研究 |
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| 引用本文： | 周丽颖,贾婵维,余兰,王树玉.荧光原位杂交技术在染色体异常中的应用研究[J].中国优生与遗传杂志,2010(4):46-47. |
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| 作者姓名： | 周丽颖 贾婵维 余兰 王树玉 |
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| 作者单位： | 首都医科大学附属北京妇产医院; |
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| 基金项目： | 北京市自然科研基金资助(No:7082033); 国家自然科研基金资助(No:30771197) |
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| 摘 要： | 目的应用荧光原位杂交（FISH）技术及细胞学对照,研究FISH产前诊断染色体异常的临床应用。方法应用5种（21、13、18、X和Y）FISH探针,平行细胞染色体分析进行565名孕妇产前诊断检测。结果565例产前诊断病历,共检出非整倍体异常核型19例,FISH检测与细胞染色体分析结果一致。结论荧光原位杂交（13,18,21,X和Y）探针,能有效检测间期羊水细胞的绝大多数非整倍体异常,且24～48h出结果。能缓解妊娠妇女的焦虑情绪。
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| 关 键 词： | 荧光原位杂交技术 产前诊断 染色体异常 |
Study of fluorescence in situ hybridization in prenatal diagnosis of chromosome abnormalities |
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| ZHOU Li-ying,MA Yan-min,JIA Chan-wei,WANG Shu-yu..Study of fluorescence in situ hybridization in prenatal diagnosis of chromosome abnormalities[J].Chinese Journal of Birth Health & Heredity,2010(4):46-47. |
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| Authors: | ZHOU Li-ying MA Yan-min JIA Chan-wei WANG Shu-yu |
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| Institution: | ZHOU Li-ying,MA Yan-min,JIA Chan-wei,WANG Shu-yu.(Beijing Obstetrics , Gynecology Hospital Affiliated to Capital Medical University,Beijing 100026,China) |
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| Abstract: | Objective:To evaluate the application of fluorescence in situ hybridization(FISH)in prenatal diagnosis of Chromosome abnormalities.In the mean time,cytogenetic karyotype analysis was performed as control.Methods:5 chromosomes(21,13,18,X and Y)were detected with FISH.Five hundred and sixty-five patients were selected for prenatal diagnosis.Results:Of all the samples,565 samples were tested.Nineteen samples were shown with abnormal karyotypes.Results of both FISH and cytogenetic karyotype analysis exhibited e... |
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| Keywords: | Fluorescence in situ hybridization Prenatal diagnosis Chromosome abnormalities |
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