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| 冻干辐照猪硬脑膜的抗原性 | |
| 引用本文： | 张友来,邹立津,辛国华,曾元临. 冻干辐照猪硬脑膜的抗原性[J]. 中国神经再生研究, 2010, 14(53): 9950-9952 |
| 作者姓名： | 张友来 邹立津 辛国华 曾元临 |
| 作者单位： | 南昌大学第一附属医院烧伤中心，江西省南昌市，330006,南昌大学第一附属医院烧伤中心，江西省南昌市，330006,南昌大学第一附属医院烧伤中心，江西省南昌市，330006,南昌大学第一附属医院烧伤中心，江西省南昌市，330006 |
| 摘 要： | 背景：抗原性是异种组织移植最主要的问题，是移植成功与否的关键。目的：观察经冻干辐照处理后的猪硬脑膜抗原性变化。方法：取新鲜猪硬脑膜，经冻干、辐照处理后分别制备成冻干猪硬脑膜、辐照猪硬脑膜和冻干辐照猪硬脑膜。分别移植于大白兔硬脑膜上，于术后3，8周行各组实验动物淋巴细胞毒实验。结果与结论：移植冻干组和辐照组淋巴细胞死亡率比较差异无显著性意义(P > 0.05)，但均高于冻干辐照组(P < 0.05)。结果提示经冻干辐照处理后的猪硬脑膜抗原性低。 |
| 关 键 词： | 冷冻干燥法；辐照；硬脑膜；抗原性；异种移植 |
| 修稿时间： | 2010-05-05 |
Antigenicity of freeze-dried irradiated pig dura mater |
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| Zhang You-lai,Zou Li-jin,Xin Guo-hua and Zeng Yuan-lin. Antigenicity of freeze-dried irradiated pig dura mater[J]. Neural Regeneration Research, 2010, 14(53): 9950-9952 | |
| Authors: | Zhang You-lai Zou Li-jin Xin Guo-hua Zeng Yuan-lin |
| Affiliation: | Burn Center, the First Affiliated Hospital of Nanchang University, Nanchang 330006, Jiangxi Province, China,Burn Center, the First Affiliated Hospital of Nanchang University, Nanchang 330006, Jiangxi Province, China,Burn Center, the First Affiliated Hospital of Nanchang University, Nanchang 330006, Jiangxi Province, China,Burn Center, the First Affiliated Hospital of Nanchang University, Nanchang 330006, Jiangxi Province, China |
| Abstract: | BACKGROUND: Antigenicity is the main problem exists in allografts transplantation and decides the fate of transplantation. OBJECTIVE: To observe the antigen changes of freeze-dried irradiated pig dura mater. METHODS: Freeze-dried porcine dura mater, irradiated porcine dura mater and freeze-dried and irradiated porcine dura mater were prepared by freeze-dried and (or) irradiated treatment and were transplanted into dura mater of white rabbits. Immunologic property was determined at 3 and 8 weeks after operation.RESULTS AND CONCLUSION: There was no significant difference of lymphocytes death rates in the freeze-dried group and irradiated group (P > 0.05), both of which were greater than that of the freeze-dried irradiated group (P < 0.05). The results demonstrated that, the pig freeze-dried irradiated dura mater has low antigenicity. |
| Keywords: | freeze-dried irradiation dura mater antigenicity xenotransplantation |
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