550例局限期小细胞肺癌放化疗达缓解者预防性脑照射后脑转移风险评估

目的:评价影响放化疗后达完全缓解、部分缓解(CR/PR)的局限期小细胞肺癌(SCLC)患者预防性脑照射(PCI)后脑转移(BM)风险、预后因素。方法:收集2002—2017年间在浙江省肿瘤医院治疗疗效达CR/PR且经PCI治疗的550例局限期SCLC患者的基本资料，回顾分析PCI后BM风险因素及预后。采用 ...

Risk assessment of brain metastasis after prophylactic cranial irradiation for 550 limited stage small cell lung cancer patients with remission after radiochemotherapy

Objective To evaluate the risk and prognostic factors of brain metastasis(BM)after prophylactic cranial irradiation(PCI)in limited stage small cell lung cancer(LS-SCLC)patients with complete and partial remission(CR/PR)after radiochemotherapy.Methods Baseline data of 550 patients with LS-SCLC who obtained CR/PR after chemoradiotherapy and received PCI in Zhejiang Cancer Hospital between 2002 and 2017 were collected.The risk of BM and clinical prognosis were retrospectively analyzed.The survival analysis was performed by Kaplan-Meier method.Multivariate prognostic analysis was conducted byCox models.Results The overall BM rate after PCI was 15.6%(86/550),with 9%(4/43),13%(7/52),and 16.5%(75/455)for stageⅠ,Ⅱ and Ⅲ patients,respectively.The median overall survival(OS)for the entire cohort was 27.9 months,and the 5-year OS rate was 31.0%.The OS was 24.9 and 30.2 months for patients with or without BM,and the 5-year OS rates were 8.9% and 36.1%(P<0.001).BM was an independent factor of OS(P<0.001).Clinical staging remained the influencing factor of OS and BM-free survival(P<0.001,P=0.027).Having tumors of≥5cm in diameter significantly increased the risk of BM(P=0.034)rather than the OS(P=0.182).The median OS of patients aged<60 years was significantly longer than those aged≥60 years(34.9 months vs.24.6 months,P=0.001).The median OS of patients irradiated with 2 times/d was 29.8 months,significantly longer than 24.5 months of those irradiated with 1 time/d(P=0.013).Age,sex,radiotherapy fraction and efficacy of radiochemotherapy(CR/PR)were not associated with the incidence rate of BM(all P>0.05).Conclusions SCLC patients with tumors of≥5cm in diameter may have a higher risk of developing BM after PCI.Patients aged<60 years achieve better OS compared with their counterparts aged≥60 years.