陕西榆林地区学龄前儿童幽门螺旋杆菌感染及影响因素评估

目的 分析陕西榆林地区儿童幽门螺旋杆菌(Helicobacter pylori,Hp)感染情况及危险因素.方法 选取2019年12月至2020年12月榆林地区有消化道症状的学龄前儿童374例,采用自制问卷调查所有研究对象个人资料、个人卫生经历和习惯(共用餐具、共用刷牙口杯、饭前便后洗手)生活习惯、社会经济状况、照顾者有...

Evaluation of helicobacter pylori infection and its influencing factors in preschool children in Yulin,Shaanxi province

Objective To analyze the infection situation and risk factors of Helicobacter pylori(Hp)in children in Yulin,Shaanxi province.Methods A total of 374 preschool children with digestive tract symptoms in Yulin area from December 2019 to December 2020 were selected.All the research object of personal data by using self-designed questionnaire(gender,age),personal experiences and health habits(common tableware,common koubei brushing your teeth,wash your hands before the rice then empress),the life habits(whether diet,koubei utilities,brushing your teeth regularly to suck finger),socioeconomic status,place of residence,with the number of living,family economic income,caregivers has a history of stomach problems(parents,nanny)And so on.The investigation method is the combination of telephone inquiry and on-site investigation.3ml fasting venous blood was collected,and the supernatant was centrifuged.Serum IL-17 and IL-10 levels were determined by ENZYme-linked immunosorbent assay,and Treg and Th17 cell levels were determined by flow cytometry.Hp infection was detected by 14C urea breath test.Univariate analysis and logistic regression were used to analyze the independent risk factors of Hp infection in children.Results Eighty-three of the 374 children were infected with Hp,and the infection rate was 22.19%.The levels of Treg and IL-10 in peripheral blood of Hp infected children were significantly lower than those of non-hp infected children(P<0.05).The levels of Th17 and IL-17 in peripheral blood of children with Hp infection were significantly higher than those without Hp infection(P<0.05).In univariate analysis,there were statistically significant differences between the two groups in age,parental education level,per capita monthly income,sharing tableware,sharing toothbrushing cups,washing hands before and after meals,sucking fingers,parents′knowledge of Hp,and caregivers′history of stomach disease(P<0.05).Logistic regression analysis showed that sharing tableware,sharing toothbrushing cups,sucking fingers,parents′lack of knowledge about Hp,and caregivers′history of gastric diseases were independent risk factors for Hp infection in children(P<0.05).Conclusion The infection rate of Hp in children is high,and Hp infection can cause immune system dysfunction in children.It is necessary to take targeted and effective clinical measures to prevent Hp infection.