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Apoptosis Induction of Centella Asiatica on Human Breast Cancer Cells |
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| Authors: | Suboj Babykutty Jose Padikkala Priya Prasanna Sathiadevan Vinod Vijayakurup Thasni Karedath Abdul Azis Priya Srinivas Srinivas Gopala |
| Affiliation: | 1Department of Biochemistry, Sree Chitra Tirunal Institute for Medial Sciences and Technology, Thiruvananthapuram 695011, Kerala, India;2Amala Cancer Research Centre, Amala Nagar, Thrissur 680 553, Kerala, India;3Division of Cancer Biology, Rajiv Gandhi Centre for Biotechnology, Thiruvananthapuram 695014, Kerala, India |
| Abstract: | The present study evaluated the ability of methanolic extract of Centella asiatica (Linn) Urban (Umbelliferae) to induce apoptosis in different cancer cell lines. MCF-7 cells emerged as the most sensitive cell line for in vitro growth inhibitory activity. C. asiatica extract induced apoptosis in MCF-7 cells as indicated by nuclear condensation, increased annexin staining, loss of mitochondrial membrane potential and induction of DNA breaks identified by TUNEL reactivity. It is possible that the use of C. asiatica extract as a component in herbal medicines could be justifiable. |
| Keywords: | Apoptosis Cancer Centella asiatica |