Aurora A、PCNA在脑胶质瘤中的表达及临床意义

目的:探讨Aurora A、PCNA在胶质瘤组织中的表达及两者的关系。方法:采用免疫组化SP法检测Aurora A和PCNA在80例手术切除的胶质瘤组织及10例正常脑组织标本中的表达情况。结果:Aurora A在胶质瘤组织中的阳性表达率57.5%(46/80),PCNA在胶质瘤组织中的阳性表达率65.0%(52/80),两者在正常脑组织中均未见表达。Aurora A和PCNA在高级别胶质瘤中的表达水平显著高于低级别组(P<0.01)。胶质瘤中Aurora A和PCNA的表达有显著相关性(P<0.01)。结论:Aurora A、PCNA的表达与胶质瘤的恶性程度密切相关,二者在胶质瘤中的发生、发展中有协同作用,并可以作为评价胶质瘤生物学行为的指标。

Expression and Clinical Significance of Aurora A and PCNA in Glioma

Objective:To explore the expression and the relationship between Aurora A and proliferating cell nuclear antigen (PCNA) protein in gliomas. Methods: The expression of Aurora A and PCNA was determined by immunohistochemistry method in 80 cases of gliomas and 10 cases of normal brain tissues. Results: The positive rate of Aurora A expression was 57.5% (46/80), and the positive rate of PCNA was 65.0% (52/80) in the gliomas patients. While no expression of Aurora A or PCNA was found in all the normal brain tissues. The expression levels of Aurora A and PCNA in high grade gliomas were significantly higher than in low grade group (P<0.01). The expression of Aurora A had positive correlation with the expression of PCNA protein (P<0.01). Conclusion: The expression of Aurora A and PCNA are related to the malignant degree of glioma, and might cooperate with each other in the tumor genesis and progression. Both Aurora A and PCNA should be considered as the indicators of the biological behavior in glioma.