胶原蛋白保存活髓的实验研究

目的　探讨胶原在修复性牙本质形成过程中的作用。方法　用Ⅰ型胶原作盖髓剂为小型猪牙盖髓 ,术后 2、4和 13周取实验牙 ,对其组织病理学改变进行光镜和透射电镜的观察。结果胶原盖髓后 2周 ,有牙本质团块形成 ,电镜下可见在基质中出现多突的成牙本质细胞样细胞。盖髓后4周 ,大部标本可见形成牙本质桥 ,电镜下可见在基质中出现退变的细胞。盖髓后 13周 ,大部标本形成牙本质桥 ,桥表层为骨样牙本质 ,深层为管状牙本质 ,电镜下可见致密的基质 ,内含紊乱的小管。结论　胶原可促进修复性牙本质形成 ,是较好的盖髓材料

Experimental study on effect of capping pulp with collagen

Objective To investigate the function of collagen on reparative dentin formation, collagen was used as capping pulp material in the teeth of minipigs Methods The histopathologic examinations and ultrastructures were observed after capping for 2 weeks, 4 weeks and 13 weeks Results After 2 weeks, the reparative dental masses were formed and the stellative cells appeared After 4 weeks, the reparative dental bridges were formed and the degenerative cells appeared in matrix After 13 weeks, the complete, think and dense dental bridges were observed Conclusions It is suggested that capping with collagen can promote formation of reparative dentine without stimulation to the pulp and that collagen can be used for capping