GSTT1基因型和吸烟状况与肺癌易感性关系

 目的：探讨GSTT1基因多态性与肺癌遗传易感性的关系及GSTT1基因多态性和性别、吸烟在肺癌易感性中的交互作用。方法：采用病例对照和PCR-RFLP)方法对100例肺癌患者和135例健康对照者外周血的GSTT1基因型进行检测，并评价其与吸烟和肺癌遗传易感性的关系。 结果：(1)GSTT1(-)基因型在肺癌组和对照组分别为57%和41.5%，二者间有显著性差异( P=0.019)。GSTT1(-)基因型的吸烟者较不吸烟者患肺癌的风险增加3.643倍(P=0.016)。吸烟者携带GSTT1(-)基因型较携带GSTT1(+)基因型患肺癌的风险增加3.286倍(P=0.006)。吸烟量≥20包年的人群中携带GSTT1(-)基因型者较携带 GSTT1(+)基因型者患肺癌的风险增加7.81倍(P=0.002)。结论：GSTT1(-)基因型增加肺癌遗传易感性，吸烟与GSTT1(-)基因型间存在互交作用，二者协同增加患肺癌的风险性。吸烟量越大且携带GSTT1(-)基因型者患肺癌的风险越高

Relationship between GSTT1 genetic polymorphism, smoking and lung cancer susceptibility

Objective: To investigate the association between the genetic polymorphism of GSTT1 and the susceptibility to lung cancer and a synergetic interactions between smoking and genetic polymorphisms on lung cancer susceptibility.Methods: A case-control study and PCR—RFLP techniques were used to identify GSTT1 genotype in 100 cases of lung cancer and 135 controls.Results: The frequency of GSTT1(-) genotype in lung cancer group and controls was 57%(57/100) and 41.5%(56/135) respectively(P=0.016). There were no gender differences of GSTT1 (-) genotype distribution. In people with GSTT1(-) genotype ,smoking markedly increased the risk for lung cancer(P=0.016).In smokers，GSTT1 (-) genotype significantly increased the risk for lung cancer(P=0.006).In smokers≥ 20 packyears，GSTT1 (-) genotype remarkably increase the risk of lung cancer (P=0.002).Conclusions:The distribution frequency of GSTT1(-) genotype was higher in lung cancer，which Might increase the genetic susceptibility to lung cancer．There might be a synergetic interaction between smoking and GSTT1(-) genotype．