| 宁国贝母生物碱的分离和结构鉴定 |
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| 引用本文： | 李清华,吴宗好,张连龙,邵理.宁国贝母生物碱的分离和结构鉴定[J].药学学报,1988,23(6):415-421. |
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| 作者姓名： | 李清华 吴宗好 张连龙 邵理 |
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| 作者单位： | 安徽省医学科学研究所 合肥
(李清华，吴宗好，张连龙)，安徽中医学院中药系 毕业实习生(邵理) |
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| 摘 要： | 从贝母新种——宁国贝母(Fritillaria ningguoensis S. C. Chen et S. F. Yin)鳞茎中分离出五个生物碱,其中碱V是一种新的生物碱,命名为宁贝新(ningpeisine),根据理化常数和光谱解析以及衍生物制备,测定其结构为N-methyl-3β-hydroxy-5α-veratranine-6-one。其余四种生物碱鉴定为浙贝甲素(peimine,verticine,Ⅰ),浙贝乙素(peiminine,verticinone,Ⅱ),异浙贝甲素(isoverticine,Ⅲ)和贝母辛(peimisine,Ⅳ)。
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| 关 键 词： | 宁国贝母 宁贝新 浙贝甲素 浙贝乙素 异浙贝甲素 贝母辛 |
| 收稿时间： | 1987-05-27 |
ISOLATION AND IDENTIFICATION OF ALKALOIDS FROM FRITILLARIA NINGGUOENSIS S.C.CHEN ET S. F. YIN |
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| QH Li,ZH Wu,LL Zhang and L Shao.ISOLATION AND IDENTIFICATION OF ALKALOIDS FROM FRITILLARIA NINGGUOENSIS S.C.CHEN ET S. F. YIN[J].Acta Pharmaceutica Sinica,1988,23(6):415-421. |
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| Authors: | QH Li ZH Wu LL Zhang and L Shao |
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| Abstract: | Ning-Guo Bei Mu, a new substitute for the traditional Chinese medicine Bei Mu (Fritillaria verticillata Willd), has been used for antibechie and expectorant. From Ning-Guo Bei Mu (the bulbs of Fritillaria ningguoensis S. C. Chen et S. F. Yin)five alkaloids including a new veratranine alkaloid were isolated. By spectral analysis (IR, MS, 1HNMR 13CNMR) and preparation of derivative the structure of this new alkaloid (Ⅴ) was elucidated as N-methyl-3β-hydroxy-5α-veratranine-6-one, named Ningpeisine. The known alkaloids were identified as verticine, verticinone, isoverticine and peimisine. |
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| Keywords: | Ningpeisine N-Methyl-3β-hydroxy-5α-veratranirte-6-one Verticine Verticinone Isoverticine Peimisine Fritillaria ningguoensis S C Chen et S F Yin |
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