| 二氢杨梅素的稳定性研究 |
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| 引用本文： | 何桂霞,裴刚,李斌,欧阳文.二氢杨梅素的稳定性研究[J].中国新药杂志,2007,16(22):1888-1890. |
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| 作者姓名： | 何桂霞 裴刚 李斌 欧阳文 |
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| 作者单位： | 湖南中医药大学药学院,长沙,410208 |
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| 摘 要： | 目的:研究二氢杨梅素在不同条件下的稳定性。方法:考察二氢杨梅素在不同pH值、温度、光线、金属离子影响下的稳定性,用反相高效液相色谱法测定其含量。结果:在pH值≤4的弱酸性条件下二氢杨梅素能稳定存在,随着pH值的增加,会加速氧化,特别是在pH值≥9的碱性条件下会立即反应而氧化变黄。温度的升高,Fe3 ,Al3 ,Cu2 等金属离子的存在以及光线均可以加速二氢杨梅素的氧化。结论:为使二氢杨梅素能较长时间稳定存在,需保证其生理活性的条件是弱酸性、避免接触Fe3 ,Al3 ,Cu2 等金属离子、避光低温保存。
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| 关 键 词： | 藤茶 二氢杨梅素 稳定性 反相高效液相色谱 |
| 文章编号： | 1003-3734（2007）22-1888-03 |
| 收稿时间： | 2007-07-12 |
| 修稿时间： | 2007年7月12日 |
Studies on stability of dihydromyricetin |
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| HE Gui-xia,PEI Gang,LI Bin,OU Yang-wen.Studies on stability of dihydromyricetin[J].Chinese Journal of New Drugs,2007,16(22):1888-1890. |
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| Authors: | HE Gui-xia PEI Gang LI Bin OU Yang-wen |
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| Abstract: | Objective:To investigate the stability of dihydromyricetin under different conditions.Methods:The effects of pH value,temperature,light and different metal ions on the stability of dihydromyricetin were observed.The contents of dihydromyricetin were determined by RP-HPLC.Results:Dihydromyricetin was stable in weak acid solution and was unstable under the conditions of basic solution,strong light,high temperature and metal ions.Conclusion:The optimum conditions for keeping the stability and antioxidative effect of dihydromyricetin were weak acidity,hypothermia,preventing from light and metal ion,such as Fe3 ,Al3 ,Cu2 . |
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| Keywords: | Ampelopsis grossedentata dihydromyricetin stability reverse phase high performance liquid chromatography(RP-HPLC) |
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