丹参注射液对实验动物同种移植心脏存活期的影响

丹参为常用活血化瘀药物。本实验表明,肌肉注射丹参注射液,可使大鼠同种异体移植心脏的存活期延长(P<0.05)。在家兔心脏移植模型中,将丹参注射液与强的松龙合用,其抗排斥效果较两者单独使用时有明显的增强(P<0.05)。

Effect of Salvia Miltiorrhiza on Survival Time of Heart Allograft in Experimental Animals

Heterotopic heart allotransplantation was performed in rats and rabbits.On the basis of successful operations,one of traditional Chinese drugs of promoting the blood circulation,Salvia miltiorrhiza was evaluated for its effect in increasing the surviral time of cardial allograft.We found that at the dose of 12 g/kg and 24og/kg per day,Salvia miltiorrhiza prolonged the survival time of cardiac allograft Significantly in rats, but there was no significant difference in allograft survival time between the two groups in which Salvia miltiorrhiza was used.In rabbit cardiac allograft model a dose of 6 g/kg per day of Salvia miltiorrhiza combined with prednisolone(5 mg/kg,administered respectively at the time of 0,2,4,6,8,11,14,17,20 days after transplantation)showed stronger anti-rejection effect than either drug used alone,No significant toxic effect was noticed in our experiment.