| 低剂量X射线照射诱导G1期阻滞的适应性反应 |
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| 引用本文： | 鞠桂芝,苏旭,范冰,刘建香,傅士波,刘树铮.低剂量X射线照射诱导G1期阻滞的适应性反应[J].中华放射医学与防护杂志,1998,18(3):148-150. |
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| 作者姓名： | 鞠桂芝 苏旭 范冰 刘建香 傅士波 刘树铮 |
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| 作者单位： | 白求恩医科大学卫生部放射生物重点实验室 |
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| 摘 要： | 目的观察低剂量Ｘ射线照射能否诱导Ｇ１期细胞阻滞。方法采用碘化丙啶（ＰＩ）荧光探针标记细胞，流式细胞术（ＦＣＭ）检测并分析细胞周期。结果证实１．５ＧｙＸ射线全身照射后１２小时，小鼠胸腺细胞发生明显Ｇ１期阻滞。而０．０７５Ｇｙ低剂量预照射可明显减轻其后１．５Ｇｙ攻击剂量所致Ｇ１期阻滞。离体照射ＥＬ－４淋巴瘤细胞也得到类似结果。结论０．０７５ＧｙＸ射线照射能诱导胸腺淋巴细胞及ＥＬ－４细胞Ｇ１期阻滞的适应性反应。
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| 关 键 词： | 低剂量辐射 G_1期阻滞 适应性反应 |
| 收稿时间： | 1997/2/28 0:00:00 |
| 修稿时间： | 1997/10/20 0:00:00 |
Adaptive response of G1 arrest induced by low dose X-rays |
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| Ju Guizhi,Su Xu,Fan Bing.Adaptive response of G1 arrest induced by low dose X-rays[J].Chinese Journal of Radiological Medicine and Protection,1998,18(3):148-150. |
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| Authors: | Ju Guizhi Su Xu Fan Bing |
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| Institution: | MH Radiobiology Research Unit, Norman Bethune University of Medical Sciences, Changchun 130021, China;MH Radiobiology Research Unit, Norman Bethune University of Medical Sciences, Changchun 130021, China;MH Radiobiology Research Unit, Norman Bethune University of Medical Sciences, Changchun 130021, China;MH Radiobiology Research Unit, Norman Bethune University of Medical Sciences, Changchun 130021, China;MH Radiobiology Research Unit, Norman Bethune University of Medical Sciences, Changchun 130021, China;MH Radiobiology Research Unit, Norman Bethune University of Medical Sciences, Changchun 130021, China |
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| Abstract: | bjective\ To investigate whether or not adaptive response of G 1 arrest could be induced by low dose radiation.\ Methods\ Flow cytometry (FCM) was used to analyze cell cycle stained with propidium iodide (PI).\ Results\ \ It was found that 12h after 1.5 Gy whole body X irradiation,G 1 arrest of thymocytes took place in Kunming mice.However,G 1 arrest was diminished when a 0.075 Gy conditioning dose was given 6h before 1.5 Gy challenge dose.The same result was also revealed in EL 4 lymphoma cell line.Conclusion\ Adaptive response of G 1 arrest could be induced by low dose X rays. |
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| Keywords: | Radiation\ G 1 arrest \ Adaptive response |
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