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| 硝酸铋预处理对顺铂肾毒性的防护作用 | |
| 引用本文： | 严忠群,王琍文,杨彤,张素英,周琴. 硝酸铋预处理对顺铂肾毒性的防护作用[J]. 中国药理学与毒理学杂志, 1992, 0(4) |
| 作者姓名： | 严忠群 王琍文 杨彤 张素英 周琴 |
| 作者单位： | 大连医学院药理教研室，大连医学院药理教研室，大连医学院药理教研室，大连医学院药理教研室，大连医学院药理教研室 大连 116023，大连 116023，大连 116023，大连 116023 山西省汾阳高级护校，大连 116023 |
| 基金项目： | 国家自然科学基金 No.38970847 |
| 摘 要： | 大鼠预先sc硝酸铋(30μmol·kg~(-1)·d~(-1))连续3d,可显著降低肾毒性剂量顺铂(5mg·kg~(-1))引起的尿蛋白含量,尿NAG活性和BUN水平的升高;并可有效地防护顺铂造成的肾脏髓层外带近端小管坏死,铋对肾脏MT合成有诱导作用,这可能与其防护顺铂的急性肾毒性有关。 |
| 关 键 词： | 硝酸铋 顺铂 肾毒性 金属硫蛋白 防护作用 |
Protective effect of bismuth nitrate pretreatment on cisplatin nephrotoxicity~1 |
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| YAN Zhong-Qun,WANG Li-Wen,YANG Tong,ZHANG Su-Ying,ZHOU Qin. Protective effect of bismuth nitrate pretreatment on cisplatin nephrotoxicity~1[J]. Chinese Journal of Pharmacology and Toxicology, 1992, 0(4) | |
| Authors: | YAN Zhong-Qun WANG Li-Wen YANG Tong ZHANG Su-Ying ZHOU Qin |
| Affiliation: | YAN Zhong-Qun,WANG Li-Wen,YANG Tong,ZHANG Su-Ying,ZHOU Qin Department of Pharmacology,Dalian Medical College,Dalian 116023 |
| Abstract: | The protective effect of pretreatment with bismuth nitrate on acute renal toxicity by cisplatin was investigated in rats. Male rats received bismuth nitrate 30 μmol·kg-1 ·?d-1 sc for 3 d and a single dose of cisplatin 5 mg ·kg-1 ip on d 4. The pretreatment with bismuth significantly protected the rats from the cisplatin-induced rise in blood urea nitrogen and the widespread tubular necrosis in the S3 segment of the proximal tubule situated in the outer stripeof the medulla, although a minor transient increase of protein and NAG in the urinary excretion was observed. In comparison with the control, a single dose of cisplatin was unable to induce the synthesis of renal MT, while the pretreatment with bismuth resulted in a 5-fold increase in the content of renal MT. The results suggest that MT preinduced by bismuth may play an important role in the protection against the acute renal toxicity of cisplatin. |
| Keywords: | bismuth nitrate cisplatin nephrotoxicity metallothionein protective effect |
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