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| 氯诺昔康治疗类风湿关节炎和骨性关节炎41例 | |
| 引用本文： | 丁悦,黄东生,刘尚礼,马若凡,李春海,戴洌. 氯诺昔康治疗类风湿关节炎和骨性关节炎41例[J]. 中国新药杂志, 2004, 13(6): 562-564 |
| 作者姓名： | 丁悦 黄东生 刘尚礼 马若凡 李春海 戴洌 |
| 作者单位： | 1. 中山大学附属第二医院,骨外科,广州,510120 2. 中山大学附属第二医院,风湿内科,广州,510120 |
| 摘 要： | 目的:研究氯诺昔康治疗类风湿关节炎和骨性关节炎的疗效及安全性.方法:类风湿关节炎(34例)和骨性关节炎(48例)所致膝关节疼痛患者分别随机双盲分成2组,试验组(n=41)行膝关节腔注射氯诺昔康(8mg,每周1次),对照组(n=41)用安慰剂,疗程为3周.对二药治疗前后的疼痛指数进行比较.结果:试验组和对照组在治疗3周后的平均疼痛指数分别减少31.80和8.20(P＜0.05),显示氯诺昔康对关节炎的疼痛有显著疗效.2组不良事件发生率分别为7.31%和4.87%,均无严重不良事件发生.结论:氯诺昔康对类风湿关节炎和骨性关节炎具有良好的镇痛抗炎作用,且耐受性良好. |
| 关 键 词： | 类风湿关节炎 骨性关节炎 氯诺昔康 |
| 文章编号： | 1003-3734(2004)06-0562-03 |
The efficacy and safety of lornoxicam in treatment of rheumatoid arthritis and osteoarthritis |
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| DING Yue,HUANG Dong-sheng,LIU Shang-li,MA Ruo-fan,LI Chun-hai,DAI Lie. The efficacy and safety of lornoxicam in treatment of rheumatoid arthritis and osteoarthritis[J]. Chinese Journal of New Drugs, 2004, 13(6): 562-564 | |
| Authors: | DING Yue HUANG Dong-sheng LIU Shang-li MA Ruo-fan LI Chun-hai DAI Lie |
| Abstract: | Objective:To study the efficacy and safety of lornoxicam in treatment of rheumatoid arthritis and osteoarthritis. Methods: The randomized and double blind study was conducted in 34 patients with rheumatoid arthritis and 48 patients with osteoarthritis.They were randomly divided to re-ceive lornoxicam 8mg/week for 3 weeks or placebo for 3 weeks. Results: After treatment, the mean Huskinssion's VAS was reduced by 31. 80 for active group and 8. 20 for control group and the incidence of ADRs was 7.31% for active group and 4. 87% for control group. Conclusion:Lornoxicam is effective in treatment of rheumatoid arthritis and osteoarthritis with mild adverse reactions. |
| Keywords: | rheumatoid arthritis osteoarthritis lor loxicam |
| 本文献已被 CNKI 万方数据 等数据库收录！ | |