| 岩白菜素大鼠在体肠吸收动力学的研究 |
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| 引用本文： | 秦瑄,周丹,黄园. 岩白菜素大鼠在体肠吸收动力学的研究[J]. 四川大学学报(医学版), 2007, 38(6): 1013-1016 |
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| 作者姓名： | 秦瑄 周丹 黄园 |
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| 作者单位： | 四川大学华西药学院,靶向药物实验室,成都,610041;四川大学华西药学院,靶向药物实验室,成都,610041;四川大学华西药学院,靶向药物实验室,成都,610041 |
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| 摘 要： | 目的 研究岩白菜素在大鼠肠道内的吸收动力学特征.方法 采用大鼠在体灌流模型,应用HPLC测定回流液和血浆中岩白菜素的含量,从吸收部位、药物浓度、pH值三方面对岩白菜素的肠吸收特性进行研究.结果 岩白菜素在0.07～0.21 mg/mL范围内的吸收具有线性动力学特征;在十二指肠、空肠、回肠和结肠的吸收各不相同;在pH5.40～7.80范围内,吸收速率随pH值增大而减小.结论 岩白菜素在大鼠全肠段均有吸收,但吸收较差,其吸收呈一级动力学过程,吸收机制主要为被动扩散.
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| 关 键 词： | 岩白菜素 在体肠吸收 HPLC |
| 修稿时间： | 2007-01-22 |
Kinetics Study on Intestinal Absorption of Bergenin in Rats |
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| QIN Xuan,ZHOU Dan,HUANG Yuan. Kinetics Study on Intestinal Absorption of Bergenin in Rats[J]. Journal of Sichuan University. Medical science edition, 2007, 38(6): 1013-1016 |
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| Authors: | QIN Xuan ZHOU Dan HUANG Yuan |
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| Affiliation: | Key Laboratory of Drug Targeting of Ministry of Education, West China School of Pharmacy, Sichuan University, Chengdu 610041, China |
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| Abstract: | Objective To study the kinetics of intestine absorption of bergenin in rats. Methods The intestine absorption of bergenin in the rats was determined by in situ perfusion. The HPLC were used to determine the concentration of bergenin in the perfusate and the plasma. The concentrations of bergenin in various sites of the intestine and the pH values were studied. Results In the range of 0.07-0.21 mg/mL, the absorption of bergenin exhibited linear kinetics. The absorption varied in the duodenum, jejunum, ileum and colon. In the range of pH5.40-7.80, with the increasing of pH value, the Ka of bergenin decreased. Conclusion Bergenin is absorbed by the entire intestine, but with limited amount.The absorption of the drug is a first-order process with the passive diffusion mechanism. |
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| Keywords: | Bergenin in situ absorption from intestine HPLC |
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