| 盐酸克班宁氰基丙烯酸正丁酯毫微粒的制备工艺研究 |
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| 引用本文： | 张晓雷,马云淑,程欣,阎红. 盐酸克班宁氰基丙烯酸正丁酯毫微粒的制备工艺研究[J]. 云南中医学院学报, 2007, 30(5): 19-24 |
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| 作者姓名： | 张晓雷 马云淑 程欣 阎红 |
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| 作者单位： | 云南中医学院中药学院,云南昆明,650200 |
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| 摘 要： | 目的:优选盐酸克班宁毫微粒的制备最佳工艺。方法:以氰基丙烯酸正丁酯为聚合材料,采用乳化聚合法制备盐酸克班宁毫微粒Cre-PBCA-NP;以包封率为评价指标,通过均匀设计法,优化制备工艺。结果:按优化工艺条件,制得载药毫微粒,包封率80%.结论:经过优化筛选出的工艺,为盐酸克班宁聚氰基丙烯酸正丁酯毫微粒的最佳制备工艺。
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| 关 键 词： | 盐酸克班宁 毫微粒 均匀设计 |
| 文章编号： | 1000-2723（2007）05-0019-06 |
| 修稿时间： | 2007-05-24 |
Study on the Preparation Procedure of Crebanine Nanoparticles |
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| ZHANG Xiao-lei,MA Yun-shu,CHENG Xin,YAN Hong. Study on the Preparation Procedure of Crebanine Nanoparticles[J]. Journal of Yunnan College of Traditional Chinese Medicine, 2007, 30(5): 19-24 |
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| Authors: | ZHANG Xiao-lei MA Yun-shu CHENG Xin YAN Hong |
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| Affiliation: | Faculty of Traditional Chinese Pharmacy, Yunnan University of TCM, Kunming Yunnan 650200, China |
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| Abstract: | Objective:To search for the best preparation procedure of Crebanine polybutylcyano acrylate nanoparticles(Cr-PBCA-NP).Methods: CrPBCA-NP was prepared by emulsing polymerization method with polybutylcyano acrylate as carrier material;the procedure was optimized by uniform design test with the envelope ratio and drug loading as the test standard.Results: Under this optimum condition,the mean diameter of the mean envelope ratio 80%.Conclusion: The obtained condition was the best preparation procedure of Cr-PBCA-NP. |
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| Keywords: | Crebanine Nanoparticles Uniform Design |
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