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| 甲状腺乳头状癌多发病灶的克隆起源研究进展 | |
| 引用本文： | 林益凯. 甲状腺乳头状癌多发病灶的克隆起源研究进展[J]. 国际肿瘤学杂志, 2007, 34(9): 668-670 |
| 作者姓名： | 林益凯 |
| 作者单位： | 浙江大学医学院附属第一医院肿瘤外科,杭州,310003 |
| 摘 要： | 多发病灶是甲状腺乳头状癌的临床特征之一，多灶比例约为18％～87％。但多灶来源于肿瘤腺内转移还是各自独立起源仍有争议。通过对RET／PTC基因重排、BRAF^V600E基因突变及X染色体失活类型的研究已表明，有相当一部分多发病灶是多克隆起源的。 |
| 关 键 词： | 甲状腺肿瘤 癌 乳头状 |
| 文章编号： | 1673-422X（2007）09-0668-03 |
| 修稿时间： | 2007-04-17 |
Advancement of clonal origin in multifocal papillary thyroid carcinoma |
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| LIN Yi-kai. Advancement of clonal origin in multifocal papillary thyroid carcinoma[J]. Journal of International Oncology, 2007, 34(9): 668-670 | |
| Authors: | LIN Yi-kai |
| Affiliation: | Department of Surgical Oncology, the First Affiliated Hospital of Medical College, Zhefiang University, Hangzhou 310003, China |
| Abstract: | The presence of multiple foci is one of the common clinical features of papillary thyroid carcinoma, frequency of muhifocal tumors ranges from 18% to 87%, But whether these foci arise from intraglandular metastases or derive from independent precursors is unsettled, Studies of RET/PTC gene rearrangements, BRAF^V600E gene mutation and patterns of X-chromosome inactivation have suggested independent clonal origin of distinct tumor foci in a significant portion of muhifocal papillary thyroid carcinoma. |
| Keywords: | Thyroid neoplasms Carcinoma, papillary |
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