噻托溴胺粉吸入剂对稳定期COPD患者运动耐量及肺功能的疗效

目的探讨稳定期COPD患者予噻托溴胺粉吸入剂治疗后运动耐量及肺功能的改善作用。方法 60例稳定期COPD患者,随机分成治疗组、对照组以及空白对照组。观察三组治疗不同时期肺功能的变化和St Georges呼吸问卷(SGRQ)情况,进行6 min步行试验观察运动耐力的变化。结果用药6个月后治疗组患者咳嗽、咳痰、气促等症状明显好转,前后比较(P<0.05),用药6个月后治疗组FEV1、FVC、FEV1/FVC及FEV1占预计值(%)、运动耐力较对照组及空白对照组改善,三组比较差异有显著性(P<0.05)。治疗组运动耐力(6MWT)增加,SGRQ评分比较治疗组明显下降(P<0.05)。结论吸入噻托溴胺粉吸入剂对稳定期COPD患者运动耐量及肺功能有改善作用,并可以减少急性发作次数,改善患者生活质量,且副反应少。

Therapeutic effect of tiotropium bromide inhalation powder on exercise tolerance and lung function in patients with stable COPD

Objective To evaluate the therapeutic effect of tiotropium bromide inhalation powder on exercise tolerance and lung function in patients with stable COPD and its possible mechanism.Methods 60 patients with stable COPD were randomly divided into treatment group,control group and blank control group.Lung function and St Georges Respiratory Questionnaire(SGRQ) were tested in three different periods of treatment.Meanwhile,exercise tolerance was observed by 6 min walk test.Results After 6 months treatment,cough,expectoration,tachypnea and other symptoms in treatment group significantly improved,and there was significant differences between before and after treatment(P<0.05),and FEV1,FVC,FEV1/FVC,FEV1 percentage of predicted value(%) and exercise tolerance in treatment group significantly improved,compared with the other two groups(P<0.05),as well as the SGRQ score significantly decreased compared with the other two groups(P<0.05).Conclusion Tiotropium bromide inhalation powder can improve the exercise tolerance and lung function in stable COPD,reduce the number of acute episodes,and improve quality of life with few side effects.