硫酸沙丁胺醇丙卡特罗治疗小儿支气管哮喘的临床对照研究

目的评价高选择行β2受体激动剂硫酸沙丁胺醇治疗小儿急性轻中度支气管哮喘是否差于丙卡特罗。方法93例诊断为小儿轻中度急性支气管哮喘患儿,随机分为硫酸沙丁胺醇组(实验组)42例,丙卡特罗组(对照组)51例。分别记录患儿用药前和用药后第3,7,10,14 d的肺功能。结果用药后实验组和对照肺功能指标(FEV1%,PEF%)与治疗前相比均有显著改善(P<0.05);实验组与对照组相比,患儿用药后第3,7,10,14 d肺功能指标FEV1%(P=0.36,0.72,0.52,0.63)和PEP%(P=0.50,0.59,0.62,0.83)差别无统计学意义。结论硫酸沙丁胺醇治疗小儿急性轻中度支气管哮喘在改善肺功能方面并不差于丙卡特罗。

A Clinical Study of Salbutamol Sulfate VS Procaterol for Treatment of Asthma in Children

Objective To evaluate whether the salbutamol sulfate was superior to procaterol for treatment of asthma in children.Methods 93 children diagnosed as mild to moderate acute bronchial asthma,were randomly divided into two groups.One group with 42 cases received albutamol sulphate(experimental group),the other group with 51 cases was received procaterol(control group).The pulmonary function were recorded before treatment and after treatment at day of 3,7,10 and 14.Results Compared with pre-treatment,the percentage of forced expiratory volumn in l second(FEV1%) and the percentage of peak expiratory flow(PEF%) were obviously improved in both trial group and control group(P<0.05).There were no differences of pulmonary function observed at the day of 3,7,10 and 14 after treatment betwenn the experimental group and control group with FEV1%(P=0.36,0.72,0.52,0.63,respectively) and PEP%(P=P=0.50,0.59,0.62,0.83,respectively).Conclusion salbutamol sulfate was not superior to procaterol for treatment of acute mild to moderate asthma on improveing pulmonary function.