围手术期质子泵抑制剂预防使用合理性分析

目的：通过对铜陵市第四人民医院围手术期质子泵抑制剂（PPI）预防使用情况的分析，为临床PPI的使用提供合理化建议。方法：采用回顾性调查方法，对我院2015年7月所有围手术期的出院病例190份进行PPI预防使用合理性评价，评价标准为药品说明书以及国内外PPI使用的循证医学研究结果。结果：我院围手术期PPI预防使用率为41.58%。不合理原因主要表现在用药指征不明显，具有使用指征的病例仅占11.39%，其余88.61%的病例无使用指征；PPI预防使用剂量过大；给药途径、时机和疗程不当。结论：我院围手术期PPI的使用合理性偏低，甚至存在滥用的情况。医院应该加强相应的干预措施，同时临床药师也应积极参与其中，为我院药物的合理使用保驾护航。

Evaluation on Rationality of Prophylactic Application of Proton Pump Inhibitors during Peri-operative Period

Objective: To investigate the situation of prophylactic use of proton pump inhibitors in perioperative patients, so as to provide a reasonable proposal for the clinical use of PPI and reduce abuse of PPI.Methods: By using retrospective method, we randomly chose 190 medical records of inpatients who used PPI and were discharged in July 2015, in order to evaluate the rationality of prophylactic application of PPI based on the dispensatory and fndings of evidence-based medicine home and abroad.Results: The prophylactic application rate of PPI in perioperative patients is 41.58%. Most of the irrationality were without obvious indications (88.61%) and some with indication (11.39%). The clinical use dosage of PPI was excessive. Some were with unreasonable route of administration, opportunity and period of treatment.Conclusion: The rationality of perioperative use of PPI in our hospital was not decent and it was even abused. Hospitals should strengthen appropriate interventions, and clinical pharmacists should also be actively involved for the rational use of drugs in our hospital.