葡萄糖酸锌颗粒辅助治疗儿童疱疹性咽峡炎疗效观察

目的:探讨葡萄糖酸锌颗粒辅助治疗儿童疱疹性咽峡炎的效果。方法:选取我院2014年4月至2015年5月收治的疱疹性咽峡炎患儿98例,采用随机数表分为对照组和观察组各49例。对照组行常规治疗:利巴韦林颗粒每天10~15 mg/kg,分3~4次服用;利巴韦林气雾剂喷雾吸入治疗,每4~5 h 1次,2揿/次;酌情给予物理降温、退热药物治疗、静脉营养支持等。观察组在常规治疗基础上加用葡萄糖酸锌颗粒10 mg/d,分2次服用。两组均持续用药5 d,观察患儿临床症状恢复时间、治疗效果及不良反应。结果:观察组治疗过程中未见明显不良反应,总有效率89.80%,高于对照组的73.47% (P<0.05);观察组退热时间、流涎消退时间、咽峡部疱疹消失时间、咽痛消失时间、恢复进食时间分别为(1.28±0.46)d、(2.11±0.69)d、(3.25±0.48)d、(2.41±0.63)d、(1.64±0.55)d,均短于对照组(P均<0.05);观察组治疗后CK-MB、CK水平分别为(13.63±3.85)U/L、(65.28±9.52)U/L,均低于对照组(P均<0.05)。结论:葡萄糖酸锌颗粒辅助治疗儿童疱疹性咽峡炎,可加快临床症状恢复,提高临床疗效。

Curative Effect of Zinc Gluconate Granule in Adjunctive Treatment of Herpangina

Objective: To explore the effect of zinc gluconate granule in adjunctive treatment of herpangina. Methods: Ninety eight cases of children with herpangina in the hospital were selected as the research objects and were divided into the control group and the observation group randomly with 49 cases in each group. The control group received routine treatment while the observation group received supplemented zinc gluconate granules for therapy based on the treatment of the control group. The recovery time of the two groups were recorded and the clinical efficacy and adverse drug reactions were evaluated. Results: In the observation group, the effective rate was 89.80% which was significantly higher than 73.47% of the control group (P<0.05). After treatment, the defervesce time, salivation regression time, herpangina disappearing time, sore throat disappearing time and eating recovery time of observation group respectively were ((128±0.46) d, (2.11±0.69) d, (3.25±0.48) d, (2.41±0.63) d and (1.64±0.55) d, which were shorten than those in the control group and the differences were statistically significant (P<0.05). After the treatment, CK-MB and CK levels in the observation group were (13.63±3.85) U/L and (65.28±9.52) U/L, respectively which were significantly lower than those in the control group and the differences were significant (P<0.05). Conclusion: In adjunctive treatment of herpangina, zinc gluconate granule can shorten the time to recovery of symptom and improve the clinical efficacy.